Food and Fermentation Industries >

2024 , Vol. 50 >Issue 15: 41 - 47

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.037031

Alleviation of black wolfberry ferment on seborrheic alopecia in mice

  • MIN Xiangbo ,
  • LI Lina ,
  • YU Ping ,
  • LI Jing ,
  • HUI Meixing ,
  • BAI Miao
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  • 1(Jiangxi Renren Health Microecological Technology Co.Ltd., Zhangshu 331200, China)
    2(School of Food Science and Engineering, Bohai University, Jinzhou 121013, China)

Received date: 2023-08-13

  Revised date: 2023-09-06

  Online published: 2024-08-21

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Abstract

This study investigated the functional effects of black wolfberry ferment in alleviating seborrheic alopecia symptoms in mice.Mice were randomly divided into control group, model group, puree group, and ferment group.A seborrheic alopecia mouse model was successfully established by subcutaneous injection of propionate testosterone.Mice in puree and ferment groups were orally administered black wolfberry fruit puree and black wolfberry fermentation liquid at 25 mL/kg·bw in 14 d, respectively.The effects on hair growth status, the number of hair follicles, collagen content, hair follicle proliferative cells, and hair follicle stem cell markers were assessed.The results indicated that both black wolfberry fruit puree and black wolfberry ferment promoted the hair growing rates, increased the number of hair follicles and the content of collagen, significantly enhanced the positive expression of the proliferative cell marker Ki67 and hair follicle stem cell marker Sox9 (P<0.05), with more pronounced effects observed in the ferment group.Metabolomics results revealed that eleven anthocyanin metabolites were upregulated in black wolfberry ferment group.The black wolfberry ferment, rich in anthocyanins, may alleviate seborrheic alopecia by regulating hair follicles growth, collagen accumulation, as well as the positive expression of hair follicle proliferative cells and hair follicle stem cells, thus possessing the potential to be developed into functional fermented foods.

Key words： black wolfberry; ferment; seborrheic alopecia; hair follicle; metabolomics

Cite this article

MIN Xiangbo , LI Lina , YU Ping , LI Jing , HUI Meixing , BAI Miao . Alleviation of black wolfberry ferment on seborrheic alopecia in mice[J]. Food and Fermentation Industries, 2024 , 50(15) : 41 -47 . DOI: 10.13995/j.cnki.11-1802/ts.037031

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