Progress of sweet-taste plants regulating glucagon-like peptide-1 against diabetes

  • WANG Yajing ,
  • CHEN Liang ,
  • ZOU Yaqian ,
  • CHEN Xumeng
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  • (School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China)

Received date: 2024-04-10

  Revised date: 2024-04-22

  Online published: 2024-08-21

Abstract

Glucagon-like peptide-1 (GLP-1), a peptide produced by intestinal L cells, can reduce blood glucose levels through multiple mechanisms, and is considered to be an effective target for the treatment of diabetes.GLP-1-related drugs such as Semaglutide have been widely used in clinical practice, with significant effects but still with some limitations.In recent years, sweet-taste plants have been widely studied and applied in the prevention and treatment of various diseases, especially in the prevention and treatment of diabetes, in which rich compounds, such as saccharides, saponins, flavonoids, and alkaloids are the main material basis of its sweet taste.A number of studies have suggested that sweet-taste plants and their active ingredients may affect GLP-1 through a variety of pathways.It directly interacts with L cells to activate taste receptors, glucagon peptide (PG)/pre hormone converting enzyme 1/3 (PC1/3), Wnt/β-catenin and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathways.What’s more, it indirectly affects the synthesis or hydrolysis of GLP-1 through gut flora/short-chain fatty acids (SCFAs), gut flora/bile acid saline hydrolytic enzyme (BSH)/farnesoid X receptor (FXR), and dipeptidyl peptidase-4 (DPP-4) pathways.This study reviews the active ingredients of sweet-taste plants and their possible mechanisms of action on GLP-1, providing new perspectives for further elucidating the taste and efficacy of sweet-taste plants.

Cite this article

WANG Yajing , CHEN Liang , ZOU Yaqian , CHEN Xumeng . Progress of sweet-taste plants regulating glucagon-like peptide-1 against diabetes[J]. Food and Fermentation Industries, 2024 , 50(15) : 372 -380 . DOI: 10.13995/j.cnki.11-1802/ts.039516

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