[1] SUN H, SAEEDI P, KARURANGA S, et al.IDF Diabetes Atlas:Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045[J].Diabetes Research and Clinical Practice, 2022, 183:109119.
[2] JUNG H, TITTEL S R, SCHLOOT N C, et al.Clinical characteristics, treatment patterns, and persistence in individuals with type 2 diabetes initiating a glucagon-like peptide-1 receptor agonist:A retrospective analysis of the Diabetes Prospective Follow-Up Registry[J].Diabetes, Obesity & Metabolism, 2023, 25(7):1813-1822.
[3] XIE Y C, ZHOU Q, HE Q J, et al.Opportunities and challenges of incretin-based hypoglycemic agents treating type 2 diabetes mellitus from the perspective of physiological disposition[J].Acta Pharmaceutica Sinica B, 2023, 13(6):2383-2402.
[4] 邹越霄, 王庆仙, 齐冬梅, 等.中药糖类提取物的定性与定量方法研究进展[J].中华中医药杂志, 2023, 38(2):710-718.
ZOU Y X, WANG Q X, QI D M, et al.Research progress on qualitative and quantitative methods of carbohydrate extracts from traditional Chinese medicine[J].China Journal of Traditional Chinese Medicine and Pharmacy, 2023, 38(2):710-718.
[5] 杨光. 多花黄精多糖对GLP-1分泌与表达的调节及其分子机制研究[D].合肥:合肥工业大学, 2018.
YANG G.The effect of Polygonatum cyrtonema Hua polysaccharides (PCP) on the expression and secretion of GLP-1 and its molecular mechanism[D].Hefei:Hefei University of Technology, 2018.
[6] KUANG M T, LI J Y, YANG X B, et al.Structural characterization and hypoglycemic effect via stimulating glucagon-like peptide-1 secretion of two polysaccharides from Dendrobium officinale[J].Carbohydrate Polymers, 2020, 241:116326.
[7] 邓姝颖. 基于GLP-1的“肠促胰素效应” 研究口服枸杞多糖的抗T2DM作用机制[D].银川:宁夏医科大学, 2021.
DENG S Y.Study on the anti-T2DM mechanism of oral lycium barbarum polysaccharide based on the “incretin effect” of GLP-1[D].Yinchuan:Ningxia Medical University, 2021.
[8] DONG Y H, WANG Z X, CHEN C, et al.A review on the hypoglycemic effect, mechanism and application development of natural dietary polysaccharides[J].International Journal of Biological Macromolecules, 2023, 253:127267.
[9] CHENG Y N, TIAN S L, CHEN Y, et al.Structural characterization and in vitro fermentation properties of polysaccharides from Polygonatum cyrtonema[J].International Journal of Biological Macromolecules, 2024, 258:128877.
[10] 张洁, 张巧铃, 卢凤来, 等.罗汉果根多糖的分离纯化及免疫活性研究[J].中草药, 2024, 55(4):1100-1109.
ZHANG J, ZHANG Q L, LU F L, et al.Isolation, purification and immunomodulatory activity of polysaccharides from roots of Siraitia grosuenorii[J].Chinese Traditional and Herbal Drugs, 2024, 55(4):1100-1109.
[11] LI Z G, AN L J, ZHANG S J, et al.Structural elucidation and immunomodulatory evaluation of a polysaccharide from Stevia rebaudiana leaves[J].Food Chemistry, 2021, 364:130310.
[12] ROZI P, ABUDUWAILI A, MA S J, et al.Isolations, characterizations and bioactivities of polysaccharides from the seeds of three species Glycyrrhiza[J].International Journal of Biological Macromolecules, 2020, 145:364-371.
[13] 魏菱鸽, 李慧, 米圣成, 等.白茅根多糖理化性质及对HepG2细胞的降糖作用研究[J/OL].食品与发酵工业, 1-16[2024-04-08].http://doi.org.hnucm.opac.vip/10.13995/j.cnki.11-1802/ts.037115.
WEI L G, LI H, MI S C, et al.Study on Physicochemical properties and hypoglycemic effects of polysaccharide from Rhizoma Alba L.on HepG2 cells[J/OL].Food and Fermentation Industry, 1-16[2024-04-08].http://doi.org.hnucm.opac.vip/10.13995/j.cnki.11-1802/ts.037115.
[14] ZHAO T, YANG M, MA L N, et al.Structural modification and biological activity of polysaccharides[J].Molecules, 2023, 28(14):5416.
[15] SONG Q B, CHENG S W, LI D, et al.Gut microbiota mediated hypoglycemic effect of Astragalus membranaceus polysaccharides in db/db mice[J].Frontiers in Pharmacology, 2022, 13:1043527.
[16] ZHANG H X, WANG Z Z, DU Z Z.Sensory-guided isolation and identification of new sweet-tasting dammarane-type saponins from Jiaogulan (Gynostemma pentaphyllum) herbal tea[J].Food Chemistry, 2022, 388:132981.
[17] SCHMID C, MITTERMEIER-KLEßINGER V, TABEA PETERS V C, et al.Quantitative mapping of flavor and pharmacologically active compounds in European licorice roots (Glycyrrhiza glabra L.) in response to growth conditions and arbuscular mycorrhiza symbiosis[J].Journal of Agricultural and Food Chemistry, 2021, 69(44):13173-13189.
[18] 戴胜, 汪惠丽.天然甜味剂罗汉果甜苷的研究进展[J].中成药, 2023, 45(2):503-509.
DAI S, WANG H L.Research progress of natural sweetener mogroside[J].Chinese Traditional Patent Medicine, 2023, 45(2):503-509.
[19] 陈絮蒙, 王雅靖, 陈靓, 等.青钱柳活性物质及其代谢调节作用的研究与应用进展[J].食品与发酵工业, 2023, 49(12):336-344.
CHEN X M, WANG Y J, CHEN L, et al.Research and application progress of active substances and their metabolic regulatory effects of Cyclocarya paliurus[J].Food and Fermentation Industries, 2023, 49(12):336-344.
[20] 田欣雨. 甜菊糖苷单体结构与其甜苦味感官表现的相关性研究[D].无锡:江南大学, 2021.
TIAN X Y.Correlation between steviol glycosides structure and their bitterness/sweetness sensory properties[D].Wuxi:Jiangnan University, 2021.
[21] LIU M Y, WANG P Y, ZHAO B L, et al.Chemical components and health benefits of Rubus suavissimus S.Lee (Chinese sweet tea) and the production method of rubusoside[J].Trends in Food Science & Technology, 2024, 143:104252.
[22] ZHANG Y L, ZHOU G S, PENG Y, et al.Anti-hyperglycemic and anti-hyperlipidemic effects of a special fraction of Luohanguo extract on obese T2DM rats[J].Journal of Ethnopharmacology, 2020, 247:112273.
[23] BAI L T, GAO J L, WEI F, et al.Therapeutic potential of ginsenosides as an adjuvant treatment for diabetes[J].Frontiers in Pharmacology, 2018, 9:423.
[24] WANG L Y, CHENG K C, LI Y X, et al.Glycyrrhizic acid increases glucagon like peptide-1 secretion via TGR5 activation in type 1-like diabetic rats[J].Biomedicine & Pharmacotherapy, 2017, 95:599-604.
[25] WEI X F, WANG Y K, LIU R T, et al.Review of natural plant-derived seco-triterpenoids and derived saponins from 2020 to 2023:New compounds, distributions, diverse activities and structure-activity relationships[J].Phytochemistry Reviews, 2024:DOI https://doi.org/10.1007/s11101-024-09917-z
[26] YANG L, YAO D D, YANG H Y, et al.Puerarin protects pancreatic β-cells in obese diabetic mice via activation of GLP-1R signaling[J].Molecular Endocrinology, 2016, 30(3):361-371.
[27] SHAKOUR Z T A, FAYEK N M, FARAG M A.How do biocatalysis and biotransformation affect citrus dietary flavonoids chemistry and bioactivity? A review[J].Critical Reviews in Biotechnology, 2020, 40(5):689-714.
[28] YANG J, HUANG Y Y, YANG Z, et al.Identification and quantitative evaluation of major sweet ingredients in sweet (Lithocarpus polystachyus Rehd.) based upon location, harvesting time, leaf age[J].Journal of the Chemical Society of Pakistan, 2018, 40(1):158.
[29] REN Z M, LIU Z H.Receptor, signal transduction and evolution of sweet, umami and bitter taste[J].Marine Life Science & Technology, 2020, 2(1):6-15.
[30] MA J, MA X L, JIANG Z B, et al.Molecular network technology for discovering new alkaloids glycosides from goji berry[J].Brazilian Journal of Botany, 2023, 46(3):573-582.
[31] ZHENG Q G, MU X Y, PAN S B, et al.Ephedrae herba:A comprehensive review of its traditional uses, phytochemistry, pharmacology, and toxicology[J].Journal of Ethnopharmacology, 2023, 307:116153.
[32] ZHANG S W, CHENG F, YANG L, et al.Chemical constituents from Glehnia littoralis and their chemotaxonomic significance[J].Natural Product Research, 2020, 34(19):2822-2827.
[33] 魏小成, 李成义, 周瑞娟, 等.无机元素与中药关系研究进展[J].中国中医药信息杂志, 2022, 29(7):140-144.
WEI X C, LI C Y, ZHOU R J, et al.Research progress in relationship between inorganic elements and Chinese materia medica[J].Chinese Journal of Information on Traditional Chinese Medicine, 2022, 29(7):140-144.
[34] BEHRENS M, LANG T.Extra-oral taste receptors-function, disease, and perspectives[J].Frontiers in Nutrition, 2022, 9:881177.
[35] VON MOLITOR E, RIEDEL K, KROHN M, et al.Sweet taste is complex:Signaling cascades and circuits involved in sweet sensation[J].Frontiers in Human Neuroscience, 2021, 15:667709.
[36] XIE S Z, YANG G, JIANG X M, et al.Polygonatum cyrtonema Hua polysaccharide promotes GLP-1 secretion from enteroendocrine L-cells through sweet taste receptor-mediated cAMP signaling[J].Journal of Agricultural and Food Chemistry, 2020, 68(25):6864-6872.
[37] YANG Z M, WANG Y, CHEN S Y.Astragalus polysaccharide alleviates type 2 diabetic rats by reversing the glucose transporters and sweet taste receptors/GLP-1/GLP-1 receptor signaling pathways in the intestine-pancreatic axis[J].Journal of Functional Foods, 2021, 76:104310.
[38] 李婷, 邓碧莲, 欧阳征海, 等.基于甜味受体整合中药“效味” 和“滋味” 探索玉竹甘味药性物质基础[J].中草药, 2023, 54(3):849-858.
LI T, DENG B L, OUYANG Z H, et al.Exploration on material basis of sweet medicinal properties of Polygonatum odoratum by integrating “effective taste” and “taste” of traditional Chinese medicine based on sweet receptors[J].Chinese Traditional and Herbal Drugs, 2023, 54(3):849-858.
[39] ORELLANA-PAUCAR A M.Steviol glycosides from Stevia rebaudiana:An updated overview of their sweetening activity, pharmacological properties, and safety aspects[J].Molecules, 2023, 28(3):1258.
[40] NOYA-LEAL F, VAN DER WIELEN N, BEHRENS M, et al.Rebaudioside A from Stevia rebaudiana stimulates GLP-1 release by enteroendocrine cells via bitter taste signalling pathways[J].Food & Function, 2023, 14(15):6914-6928.
[41] AHMAD R, DALZIEL J E.G protein-coupled receptors in taste physiology and pharmacology[J].Frontiers in Pharmacology, 2020, 11:587664.
[42] MCLEAN B A, WONG C K, CAMPBELL J E, et al.Revisiting the complexity of GLP-1 action from sites of synthesis to receptor activation[J].Endocrine Reviews, 2021, 42(2):101-132.
[43] 黄陈, 杨海峰.黄芪甲苷对2型糖尿病大鼠胰高血糖素样肽-1分泌的影响研究[J].中兽医医药杂志, 2022, 41(4):1-6.
HUANG C, YANG H F.Effect of Astragaloside Ⅳ on GLP-1 secretion in type 2 diabetic rats[J].Journal of Traditional Chinese Veterinary Medicine, 2022, 41(4):1-6.
[44] LI R S, TAO A E, YANG R M, et al.Structural characterization, hypoglycemic effects and antidiabetic mechanism of a novel polysaccharides from Polygonatum kingianum Coll.et Hemsl[J].Biomedicine & Pharmacotherapy, 2020, 131:110687.
[45] HAYAT R, MANZOOR M, HUSSAIN A.Wnt signaling pathway:A comprehensive review[J].Cell Biology International, 2022, 46(6):863-877.
[46] DEL BOSQUE-PLATA L, MARTÍNEZ-MARTÍNEZ E, ESPINOZA-CAMACHO M Á, et al.The role of TCF7L2 in type 2 diabetes[J].Diabetes, 2021, 70(6):1220-1228.
[47] NAGAHISA T, YAMAGUCHI S, KOSUGI S, et al.Intestinal epithelial NAD+ biosynthesis regulates GLP-1 production and postprandial glucose metabolism in mice[J].Endocrinology, 2022, 163(4):bqac023.
[48] 刘婷婷. 枸杞多糖经TLR4/MyD88/NF-κB信号通路对T2DM炎症因子的作用[D].银川:宁夏医科大学, 2019.
LIU T T.Effect of Lycium barbarum polysaccharide on T2DM inflammatory cytokines via TLR4/MyD88/NF-κB signaling pathway[D].Yinchuan:Ningxia Medical University, 2019.
[49] HJØRNE A P, MODVIG I M, HOLST J J.The sensory mechanisms of nutrient-induced GLP-1 secretion[J].Metabolites, 2022, 12(5):420.
[50] QI L, SHUAI T, DA J, et al.In-vitro GLP-1 release assay using STC-1 cells[J].Bio-protocol, 2020, 10(16):e3717.
[51] CHEN H E, LIU X Y, XIE M X, et al.Two polysaccharides from Rehmannia glutinosa:Isolation, structural characterization, and hypoglycemic activities[J].RSC Advances, 2023, 13(43):30190-30201.
[52] AN Y C, DAI H Y, DUAN Y H, et al.The relationship between gut microbiota and susceptibility to type 2 diabetes mellitus in rats[J].Chinese Medicine, 2023, 18(1):49.
[53] LE J M, ZHANG X Y, JIA W P, et al.Regulation of microbiota-GLP1 axis by sennoside A in diet-induced obese mice[J].Acta Pharmaceutica Sinica B, 2019, 9(4):758-768.
[54] MEADOWS V, YANG Z N, BASALY V, et al.FXR friend-ChIPs in the enterohepatic system[J].Seminars in Liver Disease, 2023, 43(3):267-278.
[55] YANG Y N, WU C M.Targeting gut microbial bile salt hydrolase (BSH) by diet supplements:New insights into dietary modulation of human health[J].Food & Function, 2022, 13(14):7409-7422.
[56] NISS K, JAKOBSSON M E, WESTERGAARD D, et al.Effects of active farnesoid X receptor on GLUTag enteroendocrine L cells[J].Molecular and Cellular Endocrinology, 2020, 517:110923.
[57] WANG Q L, LIN H B, SHEN C R, et al.Gut microbiota regulates postprandial GLP-1 response via ileal bile acid-TGR5 signaling[J].Gut Microbes, 2023, 15(2):2274124.
[58] SONG M X, TAN D H, LI B, et al.Gypenoside ameliorates insulin resistance and hyperglycemia via the AMPK-mediated signaling pathways in the liver of type 2 diabetes mellitus mice[J].Food Science and Human Wellness, 2022, 11(5):1347-1354.
[59] XIE Z F, JIANG H W, LIU W, et al.The triterpenoid sapogenin (2α-OH-protopanoxadiol) ameliorates metabolic syndrome via the intestinal FXR/GLP-1 axis through gut microbiota remodelling[J].Cell Death & Disease, 2020, 11(9):770.
[60] MATHUR V, ALAM O, SIDDIQUI N, et al.Insight into structure activity relationship of DPP-4 inhibitors for development of antidiabetic agents[J].Molecules, 2023, 28(15):5860.
[61] 顾嘉琪, 覃骊兰, 苏榕, 等.肉桂对糖尿病大鼠肠促胰素效应的调节作用[J].中国实验方剂学杂志, 2023, 29(12):104-111.
GU J Q, QIN L L, SU R, et al.Cinnamomi cortex regulates incretin effect in diabetic rats[J].Chinese Journal of Experimental Traditional Medical Formulae, 2023, 29(12):104-111.
[62] 戚志强, 田颖刚.芦笋水提物的不同膜分离部位对二肽基肽酶-Ⅳ活性的影响及其成分分析[J/OL].食品工业科技,1-11[2024-03-25].http://doi.org.hnucm.opac.vip/10.13386/j.issn1002-0306.2023090224.
QI Z Q, TIAN Y G.Effects of different membrane separation sites on the activity of dipeptidyl peptidase-Ⅳ of water extract of asparagus and its composition analysis[J/OL].Science and Technology of Food Industry,1-11[2024-03-25].http://doi.org.hnucm.opac.vip/10.13386/j.issn1002-0306.2023090224.
[63] SETYANINGSIH E P, SAPUTRI F C, MUN’IM A.The antidiabetic effectivity of Indonesian plants extracts via DPP-IV inhibitory mechanism[J].Journal of Young Pharmacists, 2019, 11(2):161-164.