[1] FLYDAL M I, MARTINEZ A.Phenylalanine hydroxylase:function, structure, and regulation[J].IUBMB Life, 2013, 65(4):341-349.
[2] ANIKSTER Y, HAACK T B, VILBOUX T, et al.Biallelic mutations in DNAJC12 cause hyperphenylalaninemia, dystonia, and intellectual disability[J].The American Journal of Human Genetics, 2017, 100(2):257-266.
[3] BLAU N, VAN SPRONSEN F J, LEVY H L.Phenylketonuria[J].The Lancet, 2010, 376(9750):1417-1427.
[4] ZOU C W, CHEN Y, LI H Y, et al.Engineered bacteria EcN-MT alleviate liver injury in cadmium-exposed mice via its probiotics characteristics and expressing of metallothionein[J].Frontiers in Pharmacology, 2022, 13:857869.
[5] LEVENTHAL D S, SOKOLOVSKA A, LI N, et al.Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity[J].Nature Communications, 2020, 11(1):2739.
[6] JIANG Y, SUN B B, QIAN F H, et al.Expression of phenylalanine ammonia lyase as an intracellularly free and extracellularly cell surface-immobilized enzyme on a gut microbe as a live biotherapeutic for phenylketonuria[J].Science China Life Sciences, 2023, 66(1):127-136.
[7] ENNS G M, KOCH R, BRUMM V, et al.Suboptimal outcomes in patients with PKU treated early with diet alone:Revisiting the evidence[J].Molecular Genetics and Metabolism, 2010, 101(2-3):99-109.
[8] SCALDAFERRI F, GERARDI V, MANGIOLA F, et al.Role and mechanisms of action of Escherichia coli Nissle 1917 in the maintenance of remission in ulcerative colitis patients:An update[J].World Journal of Gastroenterology, 2016, 22(24):5505.
[9] YAN X, LIU X Y, ZHANG D, et al.Construction of a sustainable 3-hydroxybutyrate-producing probiotic Escherichia coli for treatment of colitis[J].Cellular & Molecular Immunology, 2021, 18(10):2344-2357.
[10] KURTZ C, DENNEY W S, BLANKSTEIN L, et al.Translational development of microbiome-based therapeutics:Kinetics of E.coli Nissle and engineered strains in humans and nonhuman primates[J].Clinical and Translational Science, 2018, 11(2):200-207.
[11] SHAKIBA M, SANEIFARD H, ALAEI M R, et al.Clinical and paraclinical characteristics of non-classic phenylketonuria[J].Iranian Journal of Child Neurology, 2021, 15(3):131-138.
[12] NARDECCHIA F, MANTI F, DE LEO S, et al.Clinical characterization of tremor in patients with phenylketonuria[J].Molecular Genetics and Metabolism, 2019, 128(1-2):53-56.
[13] HODGINS D S.Yeast phenylalanine ammonia-lyase purification, properties, and the identification of catalytically essential dehydroalanine[J].Journal of Biological Chemistry, 1971, 246(9):2977-2985.
[14] ØRUM H, RASMUSSEN O F.Expression in E.coli of the gene encoding phenylalanine ammonia-lyase from Rhodosporidium toruloides[J].Applied Microbiology and Biotechnology, 1992, 36(6):745-748.
[15] GILBERT H J, CLARKE I N, GIBSON R K, et al.Molecular cloning of the phenylalanine ammonia lyase gene from Rhodosporidium toruloides in Escherichia coli K-12[J].Journal of Bacteriology, 1985, 161(1):314-320.
[16] PI J, WOOKEY P J, PITTARD A J.Cloning and sequencing of the pheP gene, which encodes the phenylalanine-specific transport system of Escherichia coli[J].Journal of Bacteriology, 1991, 173(12):3622-3629.
[17] ISABELLA V M, HA B N, CASTILLO M J, et al.Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria[J].Nature Biotechnology, 2018, 36(9):857-864.
[18] CHARBONNEAU M R, DENNEY W S, HORVATH N G, et al.Development of a mechanistic model to predict synthetic biotic activity in healthy volunteers and patients with phenylketonuria[J].Communications Biology, 2021, 4(1):898.
[19] 张雪, 温廷益.Red重组系统用于大肠杆菌基因修饰研究进展[J].中国生物工程杂志, 2008, 28(12):89-93.
ZHANG X,WEN T Y.Advances of red recombination system in Escherichia coli gene modification[J].China Biotechnology, 2008, 28(12):89-93.
[20] CHANG T M, BOURGET L, LISTER C.A new theory of enterorecirculation of amino acids and its use for depleting unwanted amino acids using oral enzyme-artificial cells, as in removing phenylalanine in phenylketonuria[J].Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, 1995, 23(1):1-21.
[21] WILLIAMS J S, THOMAS M, CLARKE D J.The gene stlA encodes a phenylalanine ammonia-lyase that is involved in the production of a stilbene antibiotic in Photorhabdus luminescens TT01[J].Microbiology, 2005, 151(Pt 8):2543-2550.
[22] CHEREPANOV P P, WACKERNAGEL W.Gene disruption in Escherichia coli:TcR and KmR cassettes with the option of Flp-catalyzed excision of the antibiotic-resistance determinant[J].Gene, 1995, 158(1):9-14.
[23] DATSENKO K A, WANNER B L.One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products[J].Proceedings of the National Academy of Sciences of the United States of America, 2000, 97(12):6640-6645.
[24] 文江平, 唐爱国.高效液相色谱法快速测定血清中的芳香族氨基酸[J].色谱, 2003, 21(2):154-157.
WEN J P, TANG A G.Rapid analysis of aromatic amino acids in serum by high performance liquid chromatography[J].Chinese Journal of Chromatography, 2003, 21(2):154-157.
[25] 王楠, 田晗, 张文晓, 等.两株具有潜在益生作用的人源链球菌的安全性评价[J].食品与发酵工业, 2021, 47(5):12-16.
WANG N, TIAN H, ZHANG W X, et al.Safety evaluation of two strains of human Streptococcus with potential probiotics[J].Food and Fermentation Industries, 2021, 47(5):12-16.
[26] 郑鹏, 田亚光, 黄贺.小鼠繁殖行为的观察与分析[J].黑龙江动物繁殖, 2013, 21(3):20-23.
ZHENG P, TIAN Y G, HUANG H.Observation and analysis of reproductive behavior of mice[J].Heilongjiang Journal of Animal Reproduction, 2013, 21(3):20-23.
[27] CRISTÓBAL-LUNA J M, CORREA-BASURTO J, MENDOZA-FIGUEROA H L, et al.Anti-epileptic activity, toxicity and teratogenicity in CD1 mice of a novel valproic acid arylamide derivative, N-(2-hydroxyphenyl)-2-propylpentanamide[J].Toxicology and Applied Pharmacology, 2020, 399:115033.
[28] YU X L, LIN C S, YU J, et al.Bioengineered Escherichia coli Nissle 1917 for tumour-targeting therapy[J].Microbial Biotechnology, 2020, 13(3):629-636.