Alleviating effect of Lactobacillus plantarum CCFM1280 on exercise-induced fatigue in mice

  • WEN Xin ,
  • TIAN Peijun ,
  • YAN Zhonghan ,
  • ZHAO Jianxin ,
  • CHEN Wei ,
  • WANG Gang
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  • (School of Food Science and Technology, Jiangnan University, Wuxi 214122, China)

Received date: 2023-11-20

  Revised date: 2024-01-19

  Online published: 2024-12-27

Abstract

The gut microbiota has been confirmed to affect the health and physiological functions of the host, and is involved in energy metabolism and regulation.Established research has proved that exercise capacity could be effectively promoted by the regulation of gut microbiota.Probiotics, as a type of microbial preparation that regulates the gut microbiota, have previously been reported to have effects such as alleviating fatigue and improving muscle damage.This study explored the role of Lactobacillus plantarum CCFM1280 in improving exercise endurance, reducing the accumulation of fatigue metabolites, and increasing energy storage.The results showed that CCFM1280 significantly increased the exhaustion swimming time of mice, reduced the levels of blood urea nitrogen and lactate dehydrogenase in serum, as well as the content of lactate in muscles.Additionally, CCFM1280 also significantly increased the content of liver glycogen and muscle glycogen, increasing energy storage during exercise.Therefore, Lactobacillus plantarum CCFM1280 has the potential to alleviate exercise fatigue.

Cite this article

WEN Xin , TIAN Peijun , YAN Zhonghan , ZHAO Jianxin , CHEN Wei , WANG Gang . Alleviating effect of Lactobacillus plantarum CCFM1280 on exercise-induced fatigue in mice[J]. Food and Fermentation Industries, 2024 , 50(23) : 29 -35 . DOI: 10.13995/j.cnki.11-1802/ts.038007

References

[1] PATIKAS D A, WILLIAMS C A, RATEL S.Exercise-induced fatigue in young people:Advances and future perspectives[J].European Journal of Applied Physiology, 2018, 118(5):899-910.
[2] ENOKA R M, DUCHATEAU J.Translating fatigue to human performance[J].Medicine and Science in Sports and Exercise, 2016, 48(11):2228-2238.
[3] CHEN H, MA X, CAO L X, et al.A multi-ingredient formula ameliorates exercise-induced fatigue by changing metabolic pathways and increasing antioxidant capacity in mice[J].Foods, 2021, 10(12):3120.
[4] LIU Y Z, LI C Y, SHEN X F, et al.The use of traditional Chinese medicines in relieving exercise-induced fatigue[J].Frontiers in Pharmacology, 2022, 13:969827.
[5] KIM H J, KIM Y J, KIM Y J, et al.Microbiota influences host exercise capacity via modulation of skeletal muscle glucose metabolism in mice[J].Experimental & Molecular Medicine, 2023, 55(8):1820-1830.
[6] SCHEIMAN J, LUBER J M, CHAVKIN T A, et al.Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism[J].Nature Medicine, 2019, 25(7):1104-1109.
[7] DOHNALOVÁ L, LUNDGREN P, CARTY J R E, et al.A microbiome-dependent gut-brain pathway regulates motivation for exercise[J].Nature, 2022, 612(7941):739-747.
[8] LI C X, PI G F, LI F.The role of intestinal flora in the regulation of bone homeostasis[J].Frontiers in Cellular and Infection Microbiology, 2021, 11:579323.
[9] LEE M C, HO C S, HSU Y J, et al.Live and heat-killed probiotic Lactobacillus paracasei PS23 accelerated the improvement and recovery of strength and damage biomarkers after exercise-induced muscle damage[J].Nutrients, 2022, 14(21):4563.
[10] LEE M C, HSU Y J, HO H H, et al.Lactobacillus salivarius subspecies salicinius SA-03 is a new probiotic capable of enhancing exercise performance and decreasing fatigue[J].Microorganisms, 2020, 8(4):545.
[11] LEE M C, CHEN M J, HUANG H W, et al.Probiotic Lactiplantibacillus plantarum Tana isolated from an international weightlifter enhances exercise performance and promotes antifatigue effects in mice[J].Nutrients, 2022, 14(16):3308.
[12] HUANG W C, PAN C H, WEI C C, et al.Lactobacillus plantarum PS128 improves physiological adaptation and performance in triathletes through gut microbiota modulation[J].Nutrients, 2020, 12(8):2315.
[13] ZHANG X Y, JING S, LIN H J, et al.Anti-fatigue effect of anwulignan via the NRF2 and PGC-1α signaling pathway in mice[J].Food & Function, 2019, 10(12):7755-7766.
[14] GONZALEZ J T, FUCHS C J, BETTS J A, et al.Liver glycogen metabolism during and after prolonged endurance-type exercise[J].American Journal of Physiology.Endocrinology and Metabolism, 2016, 311(3):E543-E553.
[15] BURNLEY M, JONES A M.Power-duration relationship:Physiology, fatigue, and the limits of human performance[J].European Journal of Sport Science, 2018, 18(1):1-12.
[16] FINSTERER J.Biomarkers of peripheral muscle fatigue during exercise[J].BMC Musculoskeletal Disorders, 2012, 13:218.
[17] MILLET G Y, MUTHALIB M, JUBEAU M, et al.Severe hypoxia affects exercise performance independently of afferent feedback and peripheral fatigue[J].Journal of Applied Physiology (Bethesda, Md., 2012, 112(8):1335-1344.
[18] PUTNAM R W.The role of lactic acid accumulation in muscle fatigue of two species of anurans, Xenopus laevis and Rana pipiens[J].Journal of Experimental Biology, 1979, 82:35-51.
[19] CHEUNG K, HUME P A, MAXWELL L.Delayed onset muscle soreness[J].Sports Medicine, 2003, 33(2):145-164.
[20] HALESTRAP A P.The SLC16 gene family-Structure, role and regulation in health and disease[J].Molecular Aspects of Medicine, 2013, 34(2-3):337-349.
[21] GOBERT A P, LATOUR Y L, ASIM M, et al.Protective role of spermidine in colitis and colon carcinogenesis[J].Gastroenterology, 2022, 162(3):813-827.
[22] CHEVALIER C, KIESER S, ÇOLAKOǦLU M, et al.Warmth prevents bone loss through the gut microbiota[J].Cell Metabolism, 2020, 32(4):575-590.
[23] BURRICHTER A G, DÖRR S, BERGMANN P, et al.Bacterial microcompartments for isethionate desulfonation in the taurine-degrading human-gut bacterium Bilophila wadsworthia[J].BMC Microbiology, 2021, 21(1):340.
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