Mechanisms and research advancements of therapeutic activity of Ampelopsis grossedentata for hyperuricemia

  • FAN Guanghe ,
  • ZHAI Zihao ,
  • LIU Jiaxin ,
  • HUANG Weidong ,
  • ZHAN Jicheng ,
  • YOU Yilin
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  • (College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China)

Received date: 2024-03-03

  Revised date: 2024-04-09

  Online published: 2024-12-30

Abstract

Hyperuricemia (HUA) is a prevalent metabolic disorder that can precipitate gout along with other severe complications.Ampelopsis grossedentata, a traditional medicinal plant, has long been utilized in traditional Chinese medicine to treat HUA and its related ailments.This review seeks to unravel the operational pathways of Ampelopsis grossedentata in mitigating HUA, spotlighting research milestones achieved to date.Initially, the article reviews the pathophysiology of HUA, focusing primarily on abnormalities in purine metabolism and uric acid excretion.An overview of current medications for the treatment of HUA, their pharmacological effects, and side effects is then provided.Then the discussion extends to assimilate findings from investigations on Ampelopsis grossedentata and its active components, indicating their roles in curtailing uric acid production, facilitating its expulsion, and fostering antioxidant and anti-inflammatory actions.Additionally, the review explores the potential mechanisms by which Ampelopsis grossedentata combats HUA, suggesting its involvement in regulating gut homeostasis and insulin resistance.Conclusively, while Ampelopsis grossedentata emerges as a formidable natural candidate for HUA management, it beckons a thorough clinical and experimental inquiry to affirm its therapeutic promise and carve its niche in clinical practice.

Cite this article

FAN Guanghe , ZHAI Zihao , LIU Jiaxin , HUANG Weidong , ZHAN Jicheng , YOU Yilin . Mechanisms and research advancements of therapeutic activity of Ampelopsis grossedentata for hyperuricemia[J]. Food and Fermentation Industries, 2024 , 50(24) : 411 -418 . DOI: 10.13995/j.cnki.11-1802/ts.039065

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