Cathartic colon is a type of intractable constipation caused by prolonged use of stimulant laxatives.Studies have shown that long-term laxative stimulation can lead to severe intestinal nerve and intestinal barrier damage.At present, there is a lack of effective treatment for cathartic colon, and the application of probiotics to alleviate gastrointestinal diseases is a current research focus.Previous studies have shown that B.longum HuNan2016 2810 has an alleviating effect on cathartic colon, but the mechanism is not yet clear.Based on this, this study aims to analyze the possible mechanism of B.longum HuNan2016 2810 in relieving cathartic colon from the perspective of intestinal nerve and intestinal barrier.It was shown that B.longum HuNan2016 2810 had a relieving effect on the cathartic colon by the measurement of constipation indicators.Further analysis of intestinal barrier and intestinal nerve indexes and their correlation with constipation relief indexes and short chain fatty acids (SCFAs) was conducted.The results showed that B.longum HuNan2016 2810 up-regulated the relative abundance of SCFAs in the intestinal tract.Increase the content of SCFAs in feces, regulate the secretion of neurotransmitters, increase the number of intestinal glial cells, repair intestinal nerves, reduce the level of inflammation in the body, regulate intestinal barrier homeostasis, and finally relieve the laxative colon.This study provides a new idea for the relief of cathartic colon.
CHENG Ting
,
LU Huimin
,
ZHANG Tong
,
WANG Linlin
,
WANG Gang
,
ZHAO Jianxin
,
CHEN Wei
. Mechanism analysis of Bifidobacterium longum HuNan2016 2810 regulating intestinal barrier homeostasis alleviating cathartic colon[J]. Food and Fermentation Industries, 2025
, 51(3)
: 35
-44
.
DOI: 10.13995/j.cnki.11-1802/ts.038867
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