Heavy metal lead ingestion can have detrimental effects on organisms, leading to irreversible damage to the kidneys and liver.Lactiplantibacillus plantarum is considered an important probiotic and has been recognized for its various advantages for organisms.This study aimed to investigate the protective effect of L. plantarum CCFM8661 against lead toxicity in mice.Using BALB/c mice, a lead poisoning mouse model was established by orally administering lead acetate solution.Enzyme-linked immunosorbent assay and histopathology were employed to evaluate the mitigating effect of L. plantarum CCFM8661 on lead toxicity in mice.Results revealed significant negative changes in body weight, antioxidant capacity, kidney tissue pathology, and tissue lead content in the model group compared to the control group, indicating the successful establishment of the model.However, supplementation with L. plantarum CCFM8661 reversed the deterioration observed in the model group, including body weight, antioxidant capacity, histopathology, and tissue lead content.Consequently, this study provides a theoretical foundation for developing probiotic treatment methods targeting chronic lead poisoning.
GUO Zhengtao
,
XIANG Fangqin
,
ZHANG Peng
,
LIU Fei
,
LI Bailiang
. Study on toxic effect of Lactiplantibacillus plantarum CCFM8661 on alleviating lead poisoning in mice[J]. Food and Fermentation Industries, 2025
, 51(3)
: 58
-63
.
DOI: 10.13995/j.cnki.11-1802/ts.037944
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