Food and Fermentation Industries >

2025 , Vol. 51 >Issue 5: 119 - 125

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.039005

Effectiveness and mechanism of fermented soybean meal in alleviating colitis in mice

  • LIU Jingyu ,
  • ZHAI Bo ,
  • YANG Xiaoyan ,
  • FANG Shuqi ,
  • MAO Yin ,
  • DENG Yu
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  • 1(National Engineering Research Center for Cereal Fermentation and Food Biomanufacturing, Jiangnan University, Wuxi 214122, China)
    2(School of Biotechnology, Jiangnan University, Wuxi 214122, China)
    3(Jiangsu Bioactive Products Processing Engineering Technology Research Center, Wuxi 214122, China)
    4(Shandong Key Laboratory of Oil and Oil Deep Processing Technology, Shandong Bohai Industrial Group Company Ltd., Binzhou 256500, China)

Received date: 2024-02-28

  Revised date: 2024-03-27

  Online published: 2025-03-28

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Abstract

To explore the alleviating effects and potential mechanisms of fermented soybean meal on colitis in mice, and seek an effective antibiotic alternative bio-feed, a dextran sulfate sodium-induced model of ulcerative colitis was employed, with treatment using fermented soybean meal by Lactobacillus plantarum DY6, to investigate the anti-inflammatory and intestinal mucosal repair capabilities.The results indicated that, both early intervention and treatment with the fermented feed significantly increased food intake and body weight of the mice, effectively reduced the mortality rate, and lowered the disease activity index scores compared to the model group.Moreover, it effectively facilitated the recovery of colonic structure from erosion, bleeding, and atrophy, significantly alleviated the increase in pro-inflammatory cytokines IL-6 and TNF-α levels, and markedly increased the expression level of closure protein in the tight junction of mouse colon tissue.The results suggested that fermented soybean meal can inhibit the signaling pathways leading to inflammation, mitigate the inflammatory response, and effectively protect the integrity of the intestinal mucosa, thereby alleviating colitis.This study provides theories and ideas for the prevention and control of animals colitis in the aquaculture industry, and is expected to develop a functional feed.

Key words： fermented soybean meal; feed; Lactobacillus plantarum; dextran sodium sulfate; colitis

Cite this article

LIU Jingyu , ZHAI Bo , YANG Xiaoyan , FANG Shuqi , MAO Yin , DENG Yu . Effectiveness and mechanism of fermented soybean meal in alleviating colitis in mice[J]. Food and Fermentation Industries, 2025 , 51(5) : 119 -125 . DOI: 10.13995/j.cnki.11-1802/ts.039005

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