Lactobacillus rhamnosus MP108 is a probiotic strain that can be used in infant food.To verify whether it has a synergistic effect with oligosaccharides in immunomodulatory functions,an immunocompromised model was constructed using Wistar rats.The method was to use 40 mg/kg BW of cyclophosphamide injected intraperitoneally for three days after successful modeling, intervention was carried out using oligosaccharides and L.rhamnosus MP108.The recovery effect of their relevant physiological indexes was observed.The results showed that the MP108 group had the best regulation of splenic index, which was not significantly different from that of the drug used as a positive control (P>0.05), while 2′-FL helped to maintain thymic index.In terms of modulation of the ability to secrete TNF-α, the 2′-FL group, the compound + MP108 group and the 2′-FL + MP108 group, on the other hand, were not significantly different (P>0.05) from that of the positive control;In terms of IL-2 secretion ability, all groups except MP108 group had similar modulation effect as the positive control.The combination of oligosaccharides and probiotics had less effect on immunoglobulin secretion.In summary, L.rhamnosus MP108 and oligosaccharides have their own advantages in regulating the various indexes of immunocompromised rats, showing synergistic effects.
YAN Haodong
,
WANG Peng
,
YU Junjuan
,
KANG Wenli
,
PAN Lina
,
WANG Jiaqi
,
LI Yisi
,
GU Ruixia
,
ZHANG Chenchen
. Study on the synergistic regulation of immune function in rats by oligosaccharides and Lactobacillus rhamnosus MP108[J]. Food and Fermentation Industries, 2025
, 51(5)
: 134
-139
.
DOI: 10.13995/j.cnki.11-1802/ts.039083
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