Indole-3-carbaldehyde (IAld), a derivative of tryptophan, is a unique metabolic product of microorganisms that has been proven in in vitro studies to have certain anti-inflammatory and anti-tumor activities.However, it is still unclear whether gut microbiota exerts related effects in vivo through the production of IAld.This study is centered on investigating the potential protective effects of a probiotic strain of Bifidobacterium animalis SHXXA4M1, which produces a high level of IAld, in a colitis-associated colorectal mouse model.The findings indicated that compared with the model group, mice in the SHXXA4M1 intervention group exhibited enhancements in several markers, including body weight, survival rate, colon length, and spleen index.Following the probiotic intervention, the relative abundance of Bifidobacterium significantly increased (P<0.05), IAld content in the colon also significantly increased (P<0.05), along with decreased levels of pro-inflammatory factors IL-1β, IL-17A, and IFN-γ, and increased levels of the anti-inflammatory factor IL-10.Additionally, there was a notable increase in the relative expression level of mRNA associated with intestinal barrier function, as well as observed apoptosis of tumor cells in the colon.The aforementioned findings suggest that supplementation of high-yield IAld Bifidobacterium animalis may mitigate inflammation in colitis-associated colorectal tumor mice through modulation of immune response and enhancement of intestinal barrier function.
LIU Yufei
,
LU Wenwei
,
ZHAO Jianxin
,
CHEN Wei
. Bifidobacterium animalis with potent indole-3-carboxaldehyde producing ability to alleviate intestinal inflammation during colorectal carcinogenesis[J]. Food and Fermentation Industries, 2025
, 51(6)
: 1
-7
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DOI: 10.13995/j.cnki.11-1802/ts.039222
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