Food and Fermentation Industries >

2025 , Vol. 51 >Issue 6: 75 - 82

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.039586

Toxicity and organ distribution characteristics of CdTe/CdS/SiO2 quantum dots in mice

  • MENG Haimei ,
  • FANG Zhijia ,
  • LI Yongbin ,
  • SUN Lijun ,
  • DENG Qi ,
  • ZHAO Yuntao
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  • (College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Zhanjiang 524088, China)

Received date: 2024-04-16

  Revised date: 2024-05-15

  Online published: 2025-04-14

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Abstract

CdTe/CdS/SiO2 quantum dots have great potential for biological applications due to their bright luminescent properties and excellent photostability, but their biosafety issues remain unclear.In this study, the subacute toxicity of CdTe/CdS/SiO2 quantum dots in mice was evaluated by single intraperitoneal injections at low (0.4 mg/kg) and high (4 mg/kg) doses.The body weights, organ coefficient, blood cell counts, oxidative indices, histopathological changes, and biodistribution were continually monitored for 42 days.Results showed that there was no significant difference in body weight and organ coefficient of mice after injection of CdTe/CdS/SiO2 quantum dots.Fluorescence observation showed that the early accumulation of CdTe/CdS/SiO2 quantum dots in organs was lung>spleen>liver>kidney>heart, which showed obvious preference in distribution.Inductively coupled plasma mass spectrometry analysis showed that CdTe/CdS/SiO2 quantum dots were accumulated in the major organs of the mice for 42 days after the injection, and they were mainly distributed in the spleen and lungs in the early and middle stages, and in the liver and kidney in the later stages.Most of the blood cell counts and oxidative indices were not significantly different between the quantum dot-treated group and the control group.In addition, no significant histopathological abnormalities were found in the CdTe/CdS/SiO2 quantum dot-treated mice compared to the control group.In short, CdTe/CdS/SiO2 quantum dots demonstrated good biocompatibility in mice.These findings provide valuable data for the safe application of quantum dots.

Key words： CdTe/CdS/SiO2 quantum dots; toxicity; distribution; accumulation; biocompatibility

Cite this article

MENG Haimei , FANG Zhijia , LI Yongbin , SUN Lijun , DENG Qi , ZHAO Yuntao . Toxicity and organ distribution characteristics of CdTe/CdS/SiO2 quantum dots in mice[J]. Food and Fermentation Industries, 2025 , 51(6) : 75 -82 . DOI: 10.13995/j.cnki.11-1802/ts.039586

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