Food and Fermentation Industries >

2025 , Vol. 51 >Issue 7: 185 - 193

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.041104

Ameliorative effects of Hovenia Dulcis fruit peduncle polysaccharides on acute alcoholic liver injury in mice

  • ZHANG Yuchao ,
  • ZHU Sijie ,
  • LIU Liangyu ,
  • HE Shasha ,
  • ZHU Yingmeng ,
  • MA Siyao ,
  • KONG Tiantian ,
  • WANG Jinliang ,
  • LIU Xudong
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  • 1(Department of Brewing Engineering, Moutai Institute, Renhuai 564507, China)
    2(Department of Food Science and Engineering, Moutai Institute, Renhuai 564507, China)
    3(College of Food Science and Engineering, Ocean University of China, Qingdao 266071, China)

Received date: 2024-09-20

  Revised date: 2024-11-08

  Online published: 2025-04-29

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Abstract

Alcoholic liver disease is one of the major causes of liver damage in China, and finding ways to improve alcohol-induced liver injury is critical.This study aimed to explore the therapeutic effects of Hovenia dulcis fruit peduncle polysaccharides (HDPs) on acute alcoholic liver injury in mice and its mechanisms.Male C57BL/6 mice were fed alcohol intragastrically for 15 days to establish an acute alcoholic liver injury mouse model.The experiment was divided into four groups (n=20), including a control group, an 11.4 μL alcohol group, a 114 μL alcohol group, and an HDPs (100 mg/kg) + 114 μL alcohol group.Serum biochemistry, histopathology, enzyme-linked immunosorbent assay, and metabolomics techniques were used to assess the effects of HDPs on blood lipids, liver function, inflammatory factors, and bile acid metabolism, as well as the expression of related genes (cyp7a1, fxr, and fgf15).Results showed that HDPs significantly reduced blood lipid levels in alcohol-exposed mice, alleviated pathological liver injury and glycogen consumption caused by alcohol, reduced the levels of pro-inflammatory cytokines interleukin-4, interferon-γ, and tumor necrosis factor-α, and improved the disorder of bile acid metabolism in alcohol-exposed mice.The results indicated that HDPs, as a natural active substance, had therapeutic effects on alcoholic liver injury, which may be achieved by regulating blood lipids, anti-inflammatory, and bile acid metabolism pathways.The study provides theoretical support for the application of Hovenia dulcis in functional food.

Key words： Hovenia dulcis fruit peduncle polysaccharides; acute alcoholic liver injury; liver metabolomics; bile acid metabolism

Cite this article

ZHANG Yuchao , ZHU Sijie , LIU Liangyu , HE Shasha , ZHU Yingmeng , MA Siyao , KONG Tiantian , WANG Jinliang , LIU Xudong . Ameliorative effects of Hovenia Dulcis fruit peduncle polysaccharides on acute alcoholic liver injury in mice[J]. Food and Fermentation Industries, 2025 , 51(7) : 185 -193 . DOI: 10.13995/j.cnki.11-1802/ts.041104

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