[1] CHIANG J Y L, FERRELL J M.Bile acids as metabolic regulators and nutrient sensors[J].Annual Review of Nutrition, 2019, 39:175-200.
[2] 杜雪儿, 王菁, 姚军虎, 等.胆汁酸肠肝循环转运蛋白及FXR对其的调控机制[J].畜牧兽医学报, 2021, 52(10):2721-2739.
DU X E, WANG J, YAO J H, et al.Bile acid enterohepatic circulation transporter and its regulatory mechanism by FXR[J].Acta Veterinaria et Zootechnica Sinica, 2021, 52(10):2721-2739.
[3] LIU J X, LI Y, SUN C, et al.Geniposide reduces cholesterol accumulation and increases its excretion by regulating the FXR-mediated liver-gut crosstalk of bile acids[J].Pharmacological Research, 2020, 152:104631.
[4] TIAN S H, CHU Q, MA S T, et al.Dietary fiber and its potential role in obesity:A focus on modulating the gut microbiota[J].Journal of Agricultural and Food Chemistry, 2023, 71(41):14853-14869.
[5] FIORUCCI S, URBANI G, BIAGIOLI M, et al.Bile acids and bile acid activated receptors in the treatment of Covid-19[J].Biochemical Pharmacology, 2024, 228:115983.
[6] FUNABASHI M, GROVE T L, WANG M, et al.A metabolic pathway for bile acid dehydroxylation by the gut microbiome[J].Nature, 2020, 582(7813):566-570.
[7] RIMAL B, COLLINS S L, TANES C E, et al.Bile salt hydrolase catalyses formation of amine-conjugated bile acids[J].Nature, 2024, 626(8000):859-863.
[8] NEUGEBAUER K A, OKROS M, GUZIOR D V, et al.B aat gene knockout alters post-natal development, the gut microbiome, and reveals unusual bile acids in mice[J].Journal of Lipid Research, 2022, 63(12):100297.
[9] 李淑玲, 李闻.胆汁酸与肠道微生态的研究进展[J].胃肠病学和肝病学杂志, 2018, 27(4):466-470.
LI S L, LI W.The relationship between bile acid and intestinal microecology[J].Chinese Journal of Gastroenterology and Hepatology, 2018, 27(4):466-470.
[10] FUCHS C D, TRAUNER M. Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology[J]. Nature Reviews Gastroenterology & Hepatology, 2022, 19(7): 432-450.
[11] CHIANG J Y L, FERRELL J M.Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy[J].American Journal of Physiology.Gastrointestinal and Liver Physiology, 2020, 318(3):554-573.
[12] 宋波, 文国琴, 王蔺.胆汁酸代谢与肠道微生物[J].微生物学杂志, 2021, 41(3):107-112.
SONG B, WEN G Q, WANG L.Intestinal microorganisms and bile acid metabolism[J].Journal of Microbiology, 2021, 41(3):107-112.
[13] 袁尔东, 郑建仙, 陈智毅.多功能大豆纤维的降脂作用及其机理探讨[J].粮食与饲料工业, 2000(7):45-47.
YUAN E D, ZHENG J X, CHEN Z Y.Effect and mechanism of decreasing serum cholesterol of multifunctional soybean fiber[J].Cereal & Feed Industry, 2000(7):45-47.
[14] NIU Y G, XIA Q, JUNG W, et al.Polysaccharides-protein interaction of Psyllium and whey protein with their texture and bile acid binding activity[J].International Journal of Biological Macromolecules, 2019, 126:215-220.
[15] DRZIKOVA B, DONGOWSKI G, GEBHARDT E, et al.The composition of dietary fibre-rich extrudates from oat affects bile acid binding and fermentation in vitro[J].Food Chemistry, 2005, 90(1-2):181-192.
[16] KERN F, BIRKNER H J, OSTROWER V S.Binding of bile acids by dietary fiber 1 2[J].The American Journal of Clinical Nutrition, 1978, 31(10):S175-S179.
[17] SINGH J, METRANI R, SHIVANAGOUDRA S R, et al.Review on bile acids:Effects of the gut microbiome, interactions with dietary fiber, and alterations in the bioaccessibility of bioactive compounds[J].Journal of Agricultural and Food Chemistry, 2019, 67(33):9124-9138.
[18] NAUMANN S, SCHWEIGGERT-WEISZ U, EGLMEIER J, et al.In vitro interactions of dietary fibre enriched food ingredients with primary and secondary bile acids[J].Nutrients, 2019, 11(6):1424.
[19] WANG Z Y, YANG L N, XUE S, et al.Molecular docking and dynamic insights on the adsorption effects of soy hull polysaccharides on bile acids[J].International Journal of Food Science & Technology, 2022, 57(6):3702-3712.
[20] GRUNDY M M L, FARDET A, TOSH S M, et al.Processing of oat:The impact on oat’s cholesterol lowering effect[J].Food & Function, 2018, 9(3):1328-1343.
[21] REPPAS C, SWIDAN S Z, TOBEY S W, et al.Hydroxypropylmethylcellulose significantly lowers blood cholesterol in mildly hypercholesterolemic human subjects[J].European Journal of Clinical Nutrition, 2009, 63(1):71-77.
[22] EUSSEN S, KLUNGEL O, GARSSEN J, et al.Support of drug therapy using functional foods and dietary supplements:Focus on statin therapy[J].British Journal of Nutrition, 2010, 103(9):1260-1277.
[23] GUNNESS P, FLANAGAN B M, GIDLEY M J.Molecular interactions between cereal soluble dietary fibre polymers and a model bile salt deduced from13C NMR titration[J].Journal of Cereal Science, 2010, 52(3):444-449.
[24] NAUMANN S, SCHWEIGGERT-WEISZ U, BADER-MITTERMAIER S, et al.Differentiation of adsorptive and viscous effects of dietary fibres on bile acid release by means of in vitro digestion and dialysis[J].International Journal of Molecular Sciences, 2018, 19(8):2193.
[25] IACCARINO N, KHAKIMOV B, MIKKELSEN M S, et al.Structurally different mixed linkage β-glucan supplements differentially increase secondary bile acid excretion in hypercholesterolaemic rat faeces[J].Food & Function, 2020, 11(1):514-523.
[26] PUSHPASS R A G, ALZOUFAIRI S, JACKSON K G, et al.Circulating bile acids as a link between the gut microbiota and cardiovascular health:Impact of prebiotics, probiotics and polyphenol-rich foods[J].Nutrition Research Reviews, 2022, 35(2):161-180.
[27] SONG X Y, SUN X M, OH S F, et al.Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis[J].Nature, 2020, 577(7790):410-415.
[28] WANG C H, ZHU C P, SHAO L M, et al.Role of bile acids in dysbiosis and treatment of nonalcoholic fatty liver disease[J].Mediators of Inflammation, 2019, 2019:7659509.
[29] WINSTON J A, THERIOT C M.Diversification of host bile acids by members of the gut microbiota[J].Gut Microbes, 2020, 11(2):158-171.
[30] ZENG H W, UMAR S, RUST B, et al.Secondary bile acids and short chain fatty acids in the colon:A focus on colonic microbiome, cell proliferation, inflammation, and cancer[J].International Journal of Molecular Sciences, 2019, 20(5):1214.
[31] HUANG S M, PANG D R, LI X, et al.A sulfated polysaccharide from Gracilaria Lemaneiformis regulates cholesterol and bile acid metabolism in high-fat diet mice[J].Food & Function, 2019, 10(6):3224-3236.
[32] CHEN Y X, LIU X Y, WU L X, et al.Physicochemical characterization of polysaccharides from Chlorella pyrenoidosa and its anti-ageing effects in Drosophila melanogaster[J].Carbohydrate Polymers, 2018, 185:120-126.
[33] LANCASTER S M, LEE-MCMULLEN B, ABBOTT C W, et al.Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans[J].Cell Host & Microbe, 2022, 30(6):848-862.
[34] 邹晓莹, 邓婕, 钟静, 等.魔芋葡甘露聚糖通过肠道菌群-胆汁酸途径发挥降脂作用[J].食品科学, 2022, 43(23):113-124.
ZOU X Y, DENG J, ZHONG J, et al.Konjac glucomannan ameliorates hyperlipidemia via gut microbiota-bile acid pathway[J].Food Science, 2022, 43(23):113-124.
[35] 傅金凤. 美食蕉(Plantain)的降血糖功能及其作用机理研究[D].广州:华南理工大学, 2021.
FU J F.The anti-hyperglycemic effects of plantain and its mechanism[D].Guangzhou:South China University of Technology, 2021.
[36] ZHANG Y J, JIANG R Q, ZHENG X J, et al.Ursodeoxycholic acid accelerates bile acid enterohepatic circulation[J].British Journal of Pharmacology, 2019, 176(16):2848-2863.
[37] ZHAO J, SONG G C, WENG F Y, et al.The choleretic role of tauroursodeoxycholic acid exacerbates alpha-naphthylisothiocyanate induced cholestatic liver injury through the FXR/BSEP pathway[J].Journal of Applied Toxicology, 2023, 43(7):1095-1103.
[38] ZHANG F, XI L L, DUAN Y T, et al.The ileum-liver Farnesoid X Receptor signaling axis mediates the compensatory mechanism of 17α-ethynylestradiol-induced cholestasis via increasing hepatic biosynthesis of chenodeoxycholic acids in rats[J].European Journal of Pharmaceutical Sciences, 2018, 123:404-415.
[39] LIN H R.Natural products as farnesoid X receptor (FXR) agonists:Their interactions with FXR ligand binding region[J].Mini-Reviews in Organic Chemistry, 2016, 13(2):97-108.
[40] CHOW M D, LEE Y H, GUO G L.The role of bile acids in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis[J].Molecular Aspects of Medicine, 2017, 56:34-44.
[41] CHEN H, CHENG J H, ZHOU S S, et al.Arabinoxylan combined with different glucans improve lipid metabolism disorder by regulating bile acid and gut microbiota in mice fed with high-fat diet[J].International Journal of Biological Macromolecules, 2021, 168:279-288.
[42] CHEN H, ZHOU S S, LI J W, et al.Xyloglucan compounded inulin or Arabinoxylan against glycometabolism disorder via different metabolic pathways:Gut microbiota and bile acid receptor effects[J].Journal of Functional Foods, 2020, 74:104162.
[43] CHENG J H, JIANG X J, LI J W, et al.Xyloglucan affects gut-liver circulating bile acid metabolism to improve liver damage in mice fed with high-fat diet[J].Journal of Functional Foods, 2020, 64:103651.
[44] 方城杰, 吴漫漫, 于海宁.膳食纤维对肠道菌群紊乱及脂代谢异常的修复作用[J].中国食品学报, 2021, 21(12):127-134.
FANG C J, WU M M, YU H N.Reparative action of dietary fiber on intestinal flora disorder and lipid metabolish[J].Journal of Chinese Institute of Food Science and Technology, 2021, 21(12):127-134.
[45] 黄诗铭. 龙须菜多糖调节脂质代谢及肠道菌群功效研究[D].广州:华南理工大学, 2019.
HUANG S M.Effect of Gracilaria lemaneiformis polysaccharide on regulating lipid metabolism and intestinal flora[D].Guangzhou:South China University of Technology, 2019.
[46] VAQUERO J, MONTE M J, DOMINGUEZ M, et al.Differential activation of the human farnesoid X receptor depends on the pattern of expressed isoforms and the bile acid pool composition[J].Biochemical Pharmacology, 2013, 86(7):926-939.
[47] SAYIN S I, WAHLSTRÖM A, FELIN J, et al.Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist[J].Cell Metabolism, 2013, 17(2):225-235.
[48] LIU X X, ZHANG Y H, LI W H, et al.Fucoidan ameliorated dextran sulfate sodium-induced ulcerative colitis by modulating gut microbiota and bile acid metabolism[J].Journal of Agricultural and Food Chemistry, 2022, 70(47):14864-14876.
[49] CHEN Q C, LIU M, ZHANG P Y, et al.Fucoidan and galactooligosaccharides ameliorate high-fat diet-induced dyslipidemia in rats by modulating the gut microbiota and bile acid metabolism[J].Nutrition, 2019, 65:50-59.
[50] GUO W L, DENG J C, PAN Y Y, et al.Hypoglycemic and hypolipidemic activities of Grifola frondosa polysaccharides and their relationships with the modulation of intestinal microflora in diabetic mice induced by high-fat diet and streptozotocin[J].International Journal of Biological Macromolecules, 2020, 153:1231-1240.
[51] FENG Z Q, DOU W, ALAXI S, et al.Modified soluble dietary fiber from black bean coats with its rheological and bile acid binding properties[J].Food Hydrocolloids, 2017, 62:94-101.
[52] YANG L N, ZHANG H Y, ZHAO Y F, et al.Chemical structure, chain conformation and rheological properties of pectic polysaccharides from soy hulls[J].International Journal of Biological Macromolecules, 2020, 148:41-48.
[53] MÄKELÄ N, ROSA-SIBAKOV N, WANG Y J, et al.Role of β-glucan content, molecular weight and phytate in the bile acid binding of oat β-glucan[J].Food Chemistry, 2021, 358:129917.
[54] LIN P C, CHEN S H, ZHONG S Y.Nutritional and chemical composition of Sargassum zhangii and the physical and chemical characterization, binding bile acid, and cholesterol-lowering activity in HepG2 cells of its fucoidans[J].Foods, 2022, 11(12):1771.
[55] DOU Z M, CHEN C, HUANG Q, et al.Comparative study on the effect of extraction solvent on the physicochemical properties and bioactivity of blackberry fruit polysaccharides[J].International Journal of Biological Macromolecules, 2021, 183:1548-1559.
[56] 孙永进. 西番莲果皮多糖的纯化、结构表征及体外降脂活性研究[D].桂林:桂林理工大学, 2023.
SUN Y J.In vitro lipid-lowering activity,purification, structuralcharacterization of polysaccharidesfractionated from passiflora edulis peel[D].Guilin:Guilin University of Technology, 2023.
[57] WU D T, HE Y, YUAN Q, et al.Effects of molecular weight and degree of branching on microbial fermentation characteristics of okra pectic-polysaccharide and its selective impact on gut microbial composition[J].Food Hydrocolloids, 2022, 132:107897.
[58] ZHANG N, HUANG C H, OU S Y.In vitro binding capacities of three dietary fibers and their mixture for four toxic elements, cholesterol, and bile acid[J].Journal of Hazardous Materials, 2011, 186(1):236-239.
[59] KAHLON T S, SHAO Q.In vitro binding of bile acids by soy bean (Glycine max), black eye bean (Vigna unguiculata), garbanzo (Cicer arietinum) and Lima bean (Phaseolus lunatus)[J].Food Chemistry, 2004, 86(3):435-440.
[60] 张馨月, 张民, 邓梅, 等.三种食物来源膳食纤维的理化性质与功能特性比较[J].现代食品科技, 2024, 40(1):102-111.
ZHANG X Y, ZHANG M, DENG M, et al.Comparison of the physicochemical properties and functional properties of insoluble dietary fiber from three food sources[J].Modern Food Science and Technology, 2024, 40(1):102-111.
[61] NAUMANN S, HALLER D, EISNER P, et al.Mechanisms of interactions between bile acids and plant compounds-a review[J].International Journal of Molecular Sciences, 2020, 21(18):6495.
[62] 蔡松铃, 刘琳, 战倩, 等.膳食纤维的黏度特性及其生理功能研究进展[J].食品科学, 2020, 41(3):224-231.
CAI S L, LIU L, ZHAN Q, et al.Viscosity characteristics and physiological functions of dietary fiber:A review[J].Food Science, 2020, 41(3):224-231.
[63] 窦祖满. 不同分子量黑莓多糖的制备、结构解析及其体外消化、酵解特性研究[D].广州:华南理工大学, 2022.
DOU Z M.Preparation, structure analysis, in vitro digestion and fermentation of blackberry polysaccharides with different molecular weights[D].Guangzhou:South China University of Technology, 2022.
[64] NAUMANN S, SCHWEIGGERT-WEISZ U, EISNER P.Characterisation of the molecular interactions between primary bile acids and fractionated lupin cotyledons (Lupinus angustifolius L.)[J].Food Chemistry, 2020, 323:126780.
[65] NAUMANN S, HALLER D, EISNER P, et al.Mechanisms of interactions between bile acids and plant compounds-a review[J].International Journal of Molecular Sciences, 2020, 21(18):6495.
[66] BEHERA S K, MISHRA S, MOHAPATRA M.Physicochemical study of dietary fiber methylcellulose and human intestinal bile salt micellar aggregates[J].Colloid and Interface Science Communications, 2021, 44:100493.
[67] GUNNESS P, GIDLEY M J.Mechanisms underlying the cholesterol-lowering properties of soluble dietary fibre polysaccharides[J].Food & Function, 2010, 1(2):149-155.
[68] AJITHKUMAR A, ANDERSSON R, SIIKA-AHO M, et al.Isolation of cellotriosyl blocks from barley β-glucan with endo-1, 4-β-glucanase from Trichoderma reesei[J].Carbohydrate Polymers, 2006, 64(2):233-238.
[69] GUNNESS P, FLANAGAN B M, SHELAT K, et al.Kinetic analysis of bile salt passage across a dialysis membrane in the presence of cereal soluble dietary fibre polymers[J].Food Chemistry, 2012, 134(4):2007-2013.
[70] MÄKELÄ N, ROSA-SIBAKOV N, WANG Y J, et al.Role of β-glucan content, molecular weight and phytate in the bile acid binding of oat β-glucan[J].Food Chemistry, 2021, 358:129917.
[71] IBRÜGGER S, KRISTENSEN M, POULSEN M W, et al.Extracted oat and barley β-glucans do not affect cholesterol metabolism in young healthy adults[J].The Journal of Nutrition, 2013, 143(10):1579-1585.