Curcumin, a natural polyphenolic compound, exhibits multiple physiological activities and potential improvements in exercise performance.This study aimed to explore the effects of curcumin on exercise performance in male ICR mice following six weeks of curcumin intervention and two weeks of swimming training.Results showed that curcumin significantly enhanced mice endurance and anti-fatigue capacity, improved serum and muscle metabolism, and increased glycogen reserves.Additionally, curcumin intervention improved gut microbiota, elevating levels of short-chain fatty acids and fatty acid amides in the intestines.Correlation analysis revealed a positive association between the relative abundance of Bacteroides xylanisolvens and Parabacteroides goldsteinii with mouse exercise performance.Overall, this study elucidates curcumin’s potential mechanisms in enhancing exercise performance through metabolic improvements, glycogen storage enhancement, and modulation of gut microbiota and associated metabolites.
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