Research on rapid screening of 90 kinds of illegally added phosphodiesterase type 5 inhibitors in liquid health foods using surface-enhanced Raman spectroscopy

  • LI Yujing ,
  • HE Hongyuan ,
  • LUAN Yujing
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  • 1(School of Criminal Investigation, People’s Public Security University of China, Beijing 100038, China)
    2(Institute of Forensic Science, Ministry of Public Security, Beijing 100038, China)

Received date: 2024-08-09

  Revised date: 2024-10-12

  Online published: 2025-08-01

Abstract

In recent years, some unscrupulous vendors have illegally added phosphodiesterase type 5 inhibitors (PDE5is) to health foods such as anti-fatigue, male enhancement, and immune regulation, posing a significant threat to consumer health.To enhance market regulation and screening efficiency, it is urgent to establish relevant on-site rapid detection methods.This study established a screening method for 90 kinds of illegal PDE5is additives in liquid health foods based on surface-enhanced Raman spectroscopy technology, using homemade gold colloid as the enhancing reagent, sodium chloride hydrochloric acid solution as the aggregating agent, and acetonitrile and sulfuric acid solution for sample pretreatment.This method boasts high sensitivity and accuracy, with detection limits ranging from 1 to 10 μg/mL, providing a technical reference for the rapid detection of illicit drugs in health supplements.

Cite this article

LI Yujing , HE Hongyuan , LUAN Yujing . Research on rapid screening of 90 kinds of illegally added phosphodiesterase type 5 inhibitors in liquid health foods using surface-enhanced Raman spectroscopy[J]. Food and Fermentation Industries, 2025 , 51(14) : 372 -379 . DOI: 10.13995/j.cnki.11-1802/ts.040698

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