Food and Fermentation Industries >

2025 , Vol. 51 >Issue 15: 275 - 285

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.041271

Effect of cow and goat milk powder intake on lactose intolerance induced by high lactose

  • SUI Heqi ,
  • ZENG Xiaoling ,
  • PAN Lina ,
  • WANG Jiaqi ,
  • LI Wei ,
  • LI Jing ,
  • WU Yue
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  • 1(National Engineering Laboratory for Deep Processing of Rice and By-products, School of Food Science and Engineering, Central South University of Forestry Science and Technology, Changsha 410000, China)
    2(Ausnutria Dairy (China) Co.Ltd., Changsha 410000, China)

Received date: 2024-10-11

  Revised date: 2024-12-02

  Online published: 2025-08-22

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Abstract

To investigate the effects of cow and goat milk powders on lactose intolerance, this study initially induced lactose intolerance in Wistar rat pups by feeding them high-lactose diets to suppress lactase activity and induce diarrhea, thereby establishing a lactose intolerance model.Subsequently, the differential impact of ingesting cow and goat milk powders on lactose intolerance was evaluated.The results showed that 67% (mass fraction) high-lactose diet rat pups exhibited persistent diarrhea and significantly suppressed serum and jejunal lactase (Lac) activity (P<0.05).Furthermore, compared to day 3, by day 7, the goat milk powder group showed a significant increase in serum Lac activity by 65.17%, a decrease in diamine oxidase (DAO) content by 26.38%, an increase in motilin (MTL) by 32.77%, and an increase in somatostatin (SS) by 74.53%, with notably the least gastrointestinal edema and inflammatory infiltration in this group;whereas, the cow milk powder group experienced a decrease in Lac activity by 14.87%, a decrease in DAO by 22.08%, an increase in MTL by 24.58%, and a decrease in SS by 35.06%, with more gastrointestinal edema and inflammation compared to the goat milk group.Correlation analysis indicated a highly significant positive correlation between serum lactase activity and both MTL and SS values (P<0.001), and a negative correlation with DAO values.Overall, goat milk powder was relatively more effective in enhancing lactase activity, improving gastrointestinal motility, and accelerating the body's adaptation to alleviate lactose intolerance reactions.

Key words： cow milk powder; goat milk powder; lactose intolerance; lactase; diarrhea; diamine oxidase; motilin; somatostatin

Cite this article

SUI Heqi , ZENG Xiaoling , PAN Lina , WANG Jiaqi , LI Wei , LI Jing , WU Yue . Effect of cow and goat milk powder intake on lactose intolerance induced by high lactose[J]. Food and Fermentation Industries, 2025 , 51(15) : 275 -285 . DOI: 10.13995/j.cnki.11-1802/ts.041271

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