This study aimed to investigate the hypoglycemic effect and hepatoprotective role of highland barley blended tea in a high-fat diet-induced hyperglycemic mouse model.Six-week-old male C57BL/6J mice were randomly assigned to one of six groups:A blank control group, a model group, a positive drug group, and three groups receiving low, medium, and high doses of highland barley blended tea, respectively.Following a 9-week modeling period, the intervention with the test samples was initiated.The body weight changes and fasting blood glucose levels of the mice were recorded, and glucose tolerance, serum lipid profiles, inflammatory cytokine levels, and the content of antioxidant and lipid metabolism-related enzymes in the liver were measured.Additionally, pathological changes in the liver tissue were analyzed.A significant reduction in body weight was observed in the high-dose highland barley blended tea group compared to the model group (P<0.05).Additionally, a substantial decrease in triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels was evident (P<0.01).Fasting blood glucose levels showed a significant decline (P<0.01), and glucose tolerance exhibited a marked improvement (P<0.01).Furthermore, the degree of liver tissue degeneration was notably alleviated in all barley blended tea dosage groups.The findings suggest that the hypoglycaemic, lipid-lowering, and weight-loss effects of barley blended tea are a result of enhanced antioxidant capacity, reduced inflammatory damage, and regulated glucose and lipid metabolism.
LIU Zhaozhan
,
YU Hong
,
HE Youhui
,
ZHANG Yun
,
CHEN Zhengxing
,
WANG Li
,
ZHANG Xinxia
,
LI Ting
,
LI Juan
. Hypoglycemic effects of highland barley blended tea in high-fat diet-induced hyperglycemic mice[J]. Food and Fermentation Industries, 2025
, 51(21)
: 63
-69
.
DOI: 10.13995/j.cnki.11-1802/ts.042171
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