Food and Fermentation Industries >

2026 , Vol. 52 >Issue 5: 101 - 110

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.042691

A designed prebiotic mixture alleviates atopic dermatitis and restores intestinal dysbiosis in mice

  • YU Xihua ,
  • WANG Yi ,
  • LI Liuruolan ,
  • CHEN Xisheng ,
  • WANG Ning ,
  • WANG Hongchao
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  • 1(Sinopharm Xingsha Pharmaceuticals (Xiamen) Co.Ltd., Xiamen 361026, China)
    2(Xiamen Key Laboratory of Maternal and Infant Health and Nutrition Products, Xiamen 361026, China)
    3(School of Food Science and Technology, Jiangnan University, Wuxi 214000, China)

Received date: 2025-03-12

  Revised date: 2025-07-14

  Online published: 2026-03-25

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Abstract

Atopic dermatitis (AD) is a type of allergic skin disorder with high occurrence frequency.In this study, multiple prebiotics with immunomodulatory properties, including fructooligosaccharides (FOS), galactooligosaccharides (GOS), xylooligosaccharides (XOS), and inulin were selected based on literature review, aiming to investigate alleviation effects of individual prebiotics and their mixture on AD symptoms.The results indicated that prebiotic intervention alleviated pathological symptoms of skin in AD mice, accompanied by reduced infiltration of allergy-associated cells, decreased levels of immunoglobulin E (IgE) in serum and inflammatory cytokines, i.e. IL-4, IL-5, IL-13, and thymic stromal lymphopoietin (TSLP) in skin tissue, along with increased levels of IFN-γ in skin tissue.Among all groups, the mixture of four prebiotics demonstrated more efficient alleviation compared to individual prebiotic components.Sequencing analysis on gut microbiota revealed that the prebiotic mixture significantly regulated community structure, increased α-diversity, markedly elevated the relative abundance of potential beneficial genera (e.g., Angelakisella and Ruminiclostridium 5), and enriched abundances of operational taxonomic units such as Erysipelotrichaceae bacterium NYU-BL-F16.Microbial interaction network and correlation analyses demonstrated that enriched gut bacteria in response to prebiotic mixture intervention were significantly associated with alterations in inflammatory-associated indexes.Collectively, the prebiotic mixture exhibited more efficient mitigation against AD, achieving synergistic effects, which would contribute to AD alleviation via routes of regulating gut microbiota and modulating immune aspects of host, and provide scientific basis for development of novel intervention strategy against AD.

Key words： probiotics; atopic dermatitis; gut microbiota; immunomodulation; gut microbiota diversity; microbe-microbe interactions

Cite this article

YU Xihua , WANG Yi , LI Liuruolan , CHEN Xisheng , WANG Ning , WANG Hongchao . A designed prebiotic mixture alleviates atopic dermatitis and restores intestinal dysbiosis in mice[J]. Food and Fermentation Industries, 2026 , 52(5) : 101 -110 . DOI: 10.13995/j.cnki.11-1802/ts.042691

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