Food and Fermentation Industries >

2026 , Vol. 52 >Issue 11: 45 - 52

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.044104

Effects of Bifidobacterium longum subsp. longum CCFM1113 and Bifidobacterium adolescentis CCFM1386 compound probiotics on metabolism and gut microbiota in prediabetes mice

  • LI Liuruolan ,
  • ZHAO Yurong ,
  • WANG Yi ,
  • YU Xihua ,
  • LU Wenwei ,
  • WANG Hongchao ,
  • WU Wenjun
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  • 1(Sinopharm Xingsha Pharmaceutical (Xiamen) Co.Ltd., Xiamen 361026, China)
    2(Xiamen Key Laboratory of Maternal and Infant Health and Nutrition Products, Xiamen 361026, China)
    3(School of Food Science and Technology, Jiangnan University, Wuxi 214122, China)
    4(Jinshan Branch of Shanghai Sixth People’s Hospital, Shanghai 201599, China)

Received date: 2025-07-31

  Revised date: 2025-09-09

  Online published: 2026-06-24

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Abstract

Prediabetes is a chronic metabolic disease with high prevalence and may develop into type II diabetes.Thus, safe and effective early intervention strategies are urgently needed.Probiotics have great potential in improving glucose metabolism, but the specific effects and potential mechanisms of compound probiotics in prediabetes remain to be further explored.Therefore, in this study, Bifidobacterium longum subsp. longum CCFM1113 and Bifidobacterium adolescentis CCFM1386 were compounded to study their effects on prediabetes mice induced by high-fat diet combined with streptozotocin (STZ).The results showed that compared with the model group, the compound probiotics significantly reduced weight gain, improved glucose tolerance, modulate glucose metabolism, and reduced insulin resistance;In addition, through histopathological analysis, it was found that the compound probiotics had protective effects on the liver and pancreas of prediabetes mice, and also significantly reduced the contents of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the liver of mice.Metagenomic sequencing of gut microbiota showed that the compound probiotics can increase microbiota diversity and help restore microbiota structure, promoting the growth of beneficial bacterial related to the regulation of metabolic disorders.The above results indicate that the compound probiotics can alleviate the symptoms of prediabetes mice by regulating metabolism and promoting the growth of beneficial bacteria.

Key words： prediabetes; compound probiotics; glucose metabolism; gut microbiota; insulin resistance

Cite this article

LI Liuruolan , ZHAO Yurong , WANG Yi , YU Xihua , LU Wenwei , WANG Hongchao , WU Wenjun . Effects of Bifidobacterium longum subsp. longum CCFM1113 and Bifidobacterium adolescentis CCFM1386 compound probiotics on metabolism and gut microbiota in prediabetes mice[J]. Food and Fermentation Industries, 2026 , 52(11) : 45 -52 . DOI: 10.13995/j.cnki.11-1802/ts.044104

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