Food and Fermentation Industries >

2026 , Vol. 52 >Issue 11: 81 - 91

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.045376

Regulatory effects of psicose-fructose syrup on glucose-lipid metabolism and gut microbiota structure in diabetic mice

  • XING Minyu ,
  • WANG Mimi ,
  • ZHANG Yali ,
  • LU Xiaoyun ,
  • RAN Ganqiao
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  • 1(Bio-Agriculture Institute of Shaanxi, Xi’an 710043, China)
    2(School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China)

Received date: 2025-12-03

  Revised date: 2026-01-19

  Online published: 2026-06-24

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Abstract

To investigate the regulatory effects of psicose-fructose syrup on glucose and lipid metabolism disorders and gut microbiota imbalance in diabetic mice, providing evidence for its application as a functional food ingredient.A diabetic mouse model was constructed using a high-energy diet combined with streptozotocin (STZ), and various proportions of D-psicose in psicose-fructose syrup were administered.The food intake, body weight, fasting blood glucose, insulin levels, oral glucose tolerance (OGTT), glycated hemoglobin (HbA1c), blood lipid profile, liver function, and thyroid function were measured.The gut microbiota structure was analyzed using 16S rRNA sequencing.Psicose-fructose syrup significantly reduced fasting blood glucose and HbA1c levels in diabetic mice, improving glucose tolerance and insulin resistance.The improvement in HbA1c and insulin levels was more pronounced with higher D-psicose content.Blood lipid analysis showed that psicose-fructose syrup significantly reduced triglyceride (TG) levels, and the high D-psicose group (DM-HPsi group) further significantly increased high-density lipoprotein cholesterol (HDL-C).Additionally, psicose-fructose syrup significantly lowered the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), alleviating liver damage in diabetic mice.Gut microbiota analysis showed significant dysbiosis in the diabetic mice model, characterized by a decreased Firmicutes/Bacteroidetes ratio, an increased proportion of Gram-negative bacteria, and a higher abundance of harmful bacteria such as Bacteroides and Alistipes.Intervention with psicose-fructose syrup significantly reversed this imbalance, restoring the Firmicutes/Bacteroidetes ratio and significantly increasing the abundance of beneficial bacteria, including Blautia, Faecalibaculum, Romboutsia, Mucispirillum and Dubosiella.Psicose-fructose syrup improves glucose and lipid metabolism disorders and liver damage in diabetic mice, exhibiting significant hypoglycemic, lipid-regulating, and hepatoprotective effects.It also effectively restores the gut microbiota structure, enhancing the abundance of beneficial bacteria, demonstrating a favorable microecological regulation effect.This study provides experimental evidence for the application of psicose-fructose syrup as a functional food in the prevention and treatment of diabetes and metabolic syndrome.

Key words： psicose-fructose syrup; diabetic; glucose and lipid metabolism; liver function; gut microbiota

Cite this article

XING Minyu , WANG Mimi , ZHANG Yali , LU Xiaoyun , RAN Ganqiao . Regulatory effects of psicose-fructose syrup on glucose-lipid metabolism and gut microbiota structure in diabetic mice[J]. Food and Fermentation Industries, 2026 , 52(11) : 81 -91 . DOI: 10.13995/j.cnki.11-1802/ts.045376

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