Flavonoids, as some dietary supplements which can promote health, prevent disease, have activities of antioxidant, anti-inflammatory, preventing cancer and so on. Due to their low toxicity and high safety, it is the best candidate for chemical prophylaxis. In the aspect of the impact on liver function, Flavonoids have the effect of anti-hepatitis, anti-liver fibrosis, anti-liver cancer, improve liver lipid metabolism, regulate liver immune function and so on.The mechanisms of protective effects of flavonoids on liver are related to anti-oxidize effect, inhibiting tumor necrosis factor, regulating cell apoptosis and so on. In order to make reasonable use of our abundant plant resources and to further study the mechanisms of dietary flavonoids in protecting liver and to better develop dietary flavonoids functional foods, we reviewed the mechanisms of protective effects of dietary flavonoids on liver in recent years both at home and abroad.