In order to set up a comprehensive evaluation system for fresh fruit drying process indicators of different wolf berry cultivars, fresh fruits epidermis wax characteristics from nine kinds cultivated in northwest region were studied by scanning electron microscope. Specific surface area, tissue water content, single fruit volume, 100-grain of fruit fresh weight and 100-grain of fruit dry weight of different Lycium barbarum L. cultivars were analyzed by One-Way ANOVA, correlation analysis, factor analysis and cluster analysis. The results showed that there were no significant differences among nine cultivars of Lycium barbarum L. in fruit shape and epidermis wax form. However, great differences of specific surface area, tissue water content, single fruit volume, 100- grain of fruit fresh weight and 100- grain of fruit dry weight was observed in different Lycium barbarum L. cultivars. Tissue water content was significantly and positively correlated with the specific surface area, whereas it was significantly and negative correlation with the 100- grain of fruit dry weight. Single fruit volume, 100- grain of fruit fresh weight and 100- grain of fruit dry weight was significantly and positively correlated with each other. Factor analysis showed that 100- grain of fruit dry weight and tissue water content were the key indicators for drying process. Meanwhile, nine Lycium barbarum L. cultivars could be divided into four types: Mengqi-1 which was classified into a cluster was the most suitable cultivar for drying process; Ningqi-0901, Ningqi-7 and Ningqi-3 were classified into the same cluster; Ningqi-0702, Ningqi-6, Ningqi-5 and Ningqi-4 were classified into the other cluster. Bianguo was classified into a cluster by itself. The latter two clusters were not suitable for drying process.