In this study, the rapid detection method based on quartz crystal microbalance gas sensor (QCM sensor) using amine-functionalized mesoporous silica nanoparticles as a sensing material was constructed for determination of formaldehyde in beers. The morphology structure and physicochemical property of materials were characterized by scanning electron microscopy, transmission electron microscopy and nitrogen adsorption-desorption. The formaldehyde sensing performance of NH2-MSN-based sensor and the detection of formaldehyde in beers were systematically investigated. The results showed that mesoporous silica nanoparticles had an average diameter of 100 nm and pore diameter of 3.5 nm, and the NH2-MSN-based sensors exhibited a low detection limit of 0.5 mg/L, a rapid response (7 s) and recovery (12 s), as well as excellent sensitivity, selectivity and stability. Furthermore, the as-fabricated sensors were utilized for determination of formaldehyde in beers. Each sample could be detected within 30 s and showed a good linear relationship. This method was fast, sensitive, and high efficiency, which had wide application prospect for the detection of formaldehyde in beers.