The ability of composite microecological preparations that contain probiotics and Agaricus bisporus powder to alleviate lead toxicity was evaluated using a lead-exposed animal model. The results showed that the microecological preparation could improve learning and memory impairments of lead-exposed mice, and the effects were superior to the chelator group. Meanwhile, the preparation could effectively increase the fecal lead content from 1 288.83 μg/g to 2 469.98 μg/g, decreased the lead level in tissues and bloods, stimulated the activity of superoxide dismutase in liver and kidney and reduced the level of malondialdehyde. In addition, it could also regulate the expressions of IL-1β, IL-6, TNF-α, and IL-8, increased the content of immunoglobulin sIgA and the relative abundance of beneficial bacteria in fecal flora. Besides, it could also improve the flora structure to protect the intestine. This study provides a theoretical basis for developing and applying microecological preparations with probiotics and Agaricus bisporus powder that can relieve lead poisoning.
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