Screen was performed to find the best material for high stability lycopene nano-microcapsule. Through comparing the physicochemical characteristics changes and measuring the particle diameter,appearance and dissolution,as well as the stability before and after freeze-drying process,we found that 5% mannito was the best in protecting the lycopene powder. The lycopenen powder contained 5 % mannitol was round or ellipse,smooth with even distributions and easy to be dissolved with(0.80±0.30)μm particle diameter. When stored at 4 ℃ for 1 month,the content of lycopene in nano-microcapsules powder without cryoprotectors and with 5% mannitol were 34.93% and 96.05 % respectively. The final products are with small particle diameter,perfect appearance and good stability and the preparation process was practical.