The response surface method was applied in optimization of the extraction of Berberis nummularia Bge Pigment.According to the principle of central combination design,the response surface method three factors at three levels was adopted.The factors of optimum conditions for the extraction were determined by regression analysis.The effects of common food additives,oxide,reductant,pH,temperature,light and different metallic ions on the stability of the pigment were studied.The results showed that the optimum conditions for the Berberis nummularia Bge.pigment extraction was as follows:75% ethanol solvents,extraction temperature 51.9℃,extraction time 2.6 h,material fluid ratio 1∶41.3;the pigment of Berberis nummularia Bge is stable to glucose and citric acid;sorbic acid and high consistence Na2S2O3 have the function of protecting the color;ascorbic acid has the discoloration;the pigment was unstable in H2O2 and light;it is better used in acid condition(pH<7)and stable to heat(<80℃);however,Fe3+,Cu2+,Pb2+ have great influence on the pigment stability.