This paper studied the variation of degradation,epimerization and de-gallate acid reaction of Epigallocatechin Gallate(EGCG) under the conditions of different heat treatment(4～100 ℃) by using the Arrhenius equation,and established the related kinetic predicting model.The results showed that the degradation,epimerization and de-gallate acid reaction of EGCG complied with the first order reaction during heat treatment,the Arrhenius equation was able to be used to fit(R2> 0.9),the rate constants went up as the temperature raised.The Ea(activation energy) and A(frequency factor) in prediction model were 53.90kJ/mol and 5.698 × 104,98.60kJ/mol and 7.315 × 1012,85.34kJ/mol and 5.112 × 1010,respectively,which indicating that the degradation of EGCG was the most easily reaction,and epimerization of EGCG was the most difficult reaction;the relative error of the model predicted value and actual value was less than 13%.Therefore,the changes of EGCG was able to be predicted according to Arrhenius equation under the condition of heat treatment.