Lignans are main medicinal ingredients in Schisandra chinensis(Turcz.)Baill.Response surface methodlogy(RSA) is used for optimizing the ultrasonic extraction technology of total lignans from caculis of Schisandra chinensis(Turcz.) Baill with ultrasonic assistance.The experiment utilizes colorimetry method to determinate the total lignan content.Based on single experiments,ultrasonic treatment time,temperature,and power are selected as independent variables.We take the extraction as a response value,and make the response surface analyzer.According to Box-Behnken central composite design,a mathematical model is established.The optimum extraction conditions was;55℃,208w for an ultrasound treatment of 12.8 min.The predicted extraction yield is 2.713%,and the yield of total lignans is(2.425 ± 0.352) %,which agrees with the actual extraction(2.425 ± 0.352) %.