Bifidobacteria are functional Probiotics,which are commonly useful to the health of organisms.Bifidobacteria have been studied widely in microbial realm,food field and medical community due to their unique functions.Bifidobactria are oxygen-sensitive bacteria,they can't convert reactive oxygen into nontoxic molecules,thus their research and application are restricted.In the future,the oxygen tolerance of Bifidobacteria will become more and more important.The oxygen tolerance and its mechanism,the methods to improve oxygen tolerance,the prospect of the Bifidobacteria products with high oxygen tolerance were reviewed in this paper aimed to provide references for future research.