Effect on production of Ganoderma lucidum in submerged culture by adding rice powder was studied,and the medium was optimized by central composite rotatable design(CCRD).The specific rates of the production on the two media were compared.The results showed that rice stalk powder with amount of 2.0%~8.0% could induce synthesis of cellulase and can be used for growth and polysaccharide production of G.lucidum.The optimized concentration of glucose and rice stalk powder were 3.26%,5.771% by response surface methodology.The yields of biomass,extracellar-polysaccharide,Intracellar-polysaccharide and Cellulase reached(14.4±0.8)U/mL,(383±9)mg/L,(329±10)mg/g,(13.22±1)g/L respectively,which were 16.1%、(22.3±0.1)%、(35.3±0.5)%、(38.9±2)% higher than those on the medium before optimization.The specific growth rate(0.031 h-1),specific production rate of EPS and IPS(EPS:0.011 h-1、IPS:8.2×10-4 h-1)was 44.6%、42.1%、18% lower than that by bean powder medium,while the specific production rate of cellulase(0.062 h-1) was 44.1% higher.Although the production in rice stalk powder medium was lower than that in the bean powder medium,it has potential using rice stalk powder to produce high additional value products.