Artemisia sacrorum Ledeb.was extracted by ultrasound and the processing was optimized.The influence of four extraction variables on extraction yields of total flavonoids was investigated,including ethanol concentration,the ratio of material to solvent,ultrasonic power and time.Based on the results of our investigations,orthogonal test design L9(34)was used to optimize the extraction yields.In addition,heat reflux and maceration were also employed to compare with ultrasonic extraction processes.The results indicated that the optimum ultrasonic extraction conditions were as follows: ethanol concentration 60%(v/v),the ratio of material to solvent 1∶ 20(w/v),ultrasonic power 350 W,time 60 min.Under the above conditions,the total ?avonoids yields could arrive 69.55 mg·g-1.Meanwhile,the optimized ultrasonic extraction processes was stable and feasible.In addition,it had several remarkable advantages,including time saving,high efficiency and easier-operation.