In this paper,the whole cell of Amycolatopsis sp.ST2710 was immobilized by alginate sodium.In order to obtain the optimal immobilization conditions for mechanical strength and conversion,some factors including alginate sodium concentration,calcium chloride concentration,immobilization time,and strain embedded volume were investigated.The optimal condition was: alginate sodium 20 g/L,calcium chloride 10 g/L,immobilization time 1 h,and 2 mL strain embedded in 10 mL beans.After immobilizing,the tolerance to lovastatin concentration was promoted greatly,starch concentration in transformation medium was obviously reduced,and the immobilization cells could be reused.Under the condition of 3 g/L lovastatin and 15 g/L starch in the transformation medium,the conversion rate reached 64% with pH 7.5 for 48 h in the first stage,and the conversion rate reached 75% with pH 5.5 for 10 h in the second stage.After 5 batches fermentation,the conversion rate still maintains at high levels.