The kinetic models of the fed-batch fermentation of cyclosporin A in 30l bioreactor were studied.Based on the fed-batch fermentation data and Logistic model,the kinetics models of cyclosporin A fermentation for cell growth,cyclosporin production and substrate consumpsion were built up.The program of origin 7.5 version was used to fit the model.The analysis results showed that the good agreement of predicted values with the experimental values,and that the kinetic models could provide reasonable descriptions for the process of cyclosporin A fed-batch fermentation.The development of fed-batch fermentation kinetics of cyclosporine A would help to regular the fermentation of cyclosporine A and increase the fermentation titer.