Plum bum(Pb) determination in red wine by graphite furnace atomic absorption spectrometry(GFAAS) was established through the research of pre-treatment method.The optimum conditions for determination of Pb in red wine were studied by five different pre-treatments.Result showed that the best matrix modifier agent was ascorbic acid,its inhalation volume was 5μL.These pre-treatments were: direct dilution,evaporation concentration,H2O2-HNO3 digestion,HClO4-HNO3 digestion and microwave digestion.The standard deviation was about 5%;the microwave dispels RSD was 3.2%.This method is rapid and accurate and can be used in the detection of Pb.