The activity of Angiotensin converting enzyme(ACE) was evaluated in the presence of 27 different kinds of wines in vitro.The results showed that all tested wines inhibited the activity of angiotensin-converting enzyme,but inhibition effects were significantly different with the differences of grape species,grape varieties and fermentation type.Among them,the Oriental Vitis species significantly was more effective than the V.vinifera,and red wines was more effective than white.When the impacts of ethanol,organic acids and polyphenols on ACE activity were analyzed,it was observed that ethanol in wines had no significant effect on ACE activity and the total content of acids showed no significant correlation with the inhibition rate of ACE while total content of phenols showed a significant correlation.Our results showed that polyphenols are beneficial in inhibiting ACE activity.