Quorum sensing is an important way for bacteria to control its group behaviors.LuxS-mediated quorum sensing widely exists in many species of bacteria.AI-2 used as autoinducer of LuxS-mediated system plays an important role in cell to cell communication.LuxS-mediated system makes a significant effect on fermentation process controlled by multiple latic acid bacteria(LAB).This paper reviews the way of AI-2 synthesis and transduction.We will also focus on the changes of protein expression and gene transcription regulated by LuxS-mediated system under the condition of co-culture among LABs.Researching in LuxS-mediated system will further reveal the mechanism of multiple LABs jointly working in fermentation and make it possible to control sourdough LABs' group behaviors in the molecular level.