Mulberry powder was produced by fresh mulberry and maltodextrin as wall material through Centrifugal Spay Drying technology.Through single factor experiment and orthogonal experiment,the influence of the Centrifugal Spay Drying processing parameters such as inlet air temperature,outlet air temperature,and rotation rate to the product quality were studied.The processes evaluated by the yield rate of powder,water content and vitamin C content.The optimum production conditions were: the inlet temperature was 200℃,the outlet temperature was 100℃,the rotation rate was 260 r/min,and the pump flow speed was 24 mL/min.The Centrifugal Spay Drying technology is a very useful technology which use less energy and highly efficient.It will help to broaden the comprehensive utilization of mulberry in the fields of food and medical industries and provide the guidance to the mulberry powder industrial production.