The safety of dairy products has been an increasing public concern in China,especially that of milk powder.At present,the main factors of deterioration are three types of chemical reactions: Lipid oxidation,Maillard reaction and lactose crystallization during milk's processing and storage.Their interaction mechanism is not clear.In this paper,research progress on the chemical changes and their impact factors,determination methods and the interaction are reviewed,research direction of chemical reactions in milk powder storage are prospected.This research will provide the theory in further study of the quality and safety control of milk powder.