Oxidative stress is main reason of the aging and cardiovascular disease.The wine can be used as an antioxidant to anti-aging and reduce the incidence of the disease to some extent.This article describes the progress of researches on wine in recent years from four aspects,i.e.antioxidant capacity,antioxidant mechanisms,vitro antioxidant ability of different composition in wine,and intracorporal(animal and human) antioxidant ability.This article provides the comprehensive analysis of the current situation and the outlook of researching direction of antioxidant of the wine.