The effect of Buckwheat-Spirulina Compound Tablet( BS) on inhibition of blood sugar level and its security in normal and experimental hyperglycemia mice were investigated. Methods Normal and alloxan-induced hyperglycemia model mice were used,the glucose tolerance and hypoglycemic of BS were tested. The method of Maximum Tolerated Dose( MTD) was used to carry out the acute oral toxicity test on mice. Results Compared with blank,0. 50,1. 50g / kg BW BS obviously reduced the level of fasting blood-glucose and area under curve of glucose in glucose tolerance experiment of hyperglycemia model mice,the nor-sugar rate were 20. 05%( P < 0. 05) and 30. 79%( P <0. 01) respectively. The area under curve of glucose were 25. 9( P <0. 05) and 24. 9( P <0. 01) respectively.BS had no significant effect on the level of fasting blood-glucose and glucose tolerance experiment of normal mice( P> 0. 05). BS didn't show statistically significant to the avoirdupois and the viscera / body ratio of normal and the model mice. The experiment of safety evaluation showed that the MTD was greater than 18. 0g / kg BW. Conclusion BS had certain assistance to the experimental hyperglycemia mice on the hypoglycemic effect. It didn't influenced the level of fasting blood-glucose and glucose tolerance experiment of the normal mice,and had no obvious side effects. Thus it should be safe in application and would be valuable for popularization.