A three-dimensional heat transfer model was established to simulate thermal sterilization of model liquids( 0.85% CMC solution) in this paper.Experiments were run with 0.85% CMC solution in can and the temperatures of geometric center weredetermined by the wireless real-time temperature recorder.Results obtained by COMSOL Multiphysics for temperature profiles were in good agreement with experimentally determined values.After validation, further simulations were carried out with the same volume of different ratios of height to diameter and orientation angles.The sterilization time increased with ratio of height to diameter and orientation angle and passed through a maximum around an ratio of height to diameter 0.75 ~ 1,then reduced gradually.When ratio of height to diameter was less than 0.75,the sterilization time reduced to a minimum around an orientation angle 0°.When ratio of height to diameter was more than 0.75,the sterilization time reduced to a minimum around an orientation angle 90°.When ratio of height to diameter was equal to 0.75,the sterilization time reduced to a minimum around an orientation angle 0° and 90°.The maximum and minimum velocity were found to be 2.83mm/s and 1.22mm/s with ratio of height to diameter 0.75,orientation angle 0° and ratio of height to diameter 0.25,orientation angle 45° respectively in all of cans for the Slowing Heating Zone( SHZ) to reach the value of 100℃ 。This study was expected to be a significant contribution for further optimization studies.