Chicken fat and lard was used as raw materials and different heat reaction models were established with sodium chloride. GC-MS were used to analysis of 3-MCPD during the reaction. Orthogonal tests were performed to find out the influence of raw materials usage,reaction temperature and time on producing 3-MCPD. The mechanism 3-MPCD formation was also discussed. The results showed that temperature had a great effect: Temperature above 140℃ could greatly promote the formation of 3-MCPD; Higher concentrations of NaCl could inhibit the growth of 3-MCPD; 3-MCPD was negative correlated with the amount of oil in the reactions,the more oils,the less 3-MCPD was produced. The longer the reaction time,the more 3-MCPD was produced.