This review introduces the management of Microbial Food Culture( MFC) in EU and aims to provide reference for the improvement of China national regulatory system in this field. In EU,Qualified Presumption of Safety( QPS) is established by European Food Safety Authority to assess the safety of MFC in the context of notifications for market authorization. And the QPS is based on four following pillars: establishing identity,body of knowledge,possible pathogenicity and end use. Authorized biological agents will be considered as"qualifications"with a recommendation for the QPS list. The list of QPS-recommended MFC is reviewed and updated annually.