A method for the determination of phenolic acids in beer based on solid-phase extraction( SPE) and high performance liquid chromatography( HPLC) was developed. The beer samples were purified with Oasis HLB solid phase extraction cartridges,and the separation of 15 phenolic acids compounds including gallic acid were performed on a ZORBAX ODS column( 4. 6 mm ×250 mm,5 μm) with the mobile phase of methanol( 0. 1% acetic acid) /water( 0. 1% acetic acid) in a gradient elution mode. The flow rate of the mobile phase was 1. 0 mL/min,and the detection wavelength was280nm. The recoveries were ranged from 90% ~118%,and the relative standard deviations( RSD) were less than 5. 0%.The method was simple,accurate,and sensitive and suitable for the determination of phenolic acids in beer.