In this paper,liquid chromatography tandem mass spectrometry was used to determine perfluorobutanesulfonate,perfluorohexanesulfonate,perfluorooctanesulfonate,perfluorodecanesulfonate,perfluorohexanoate,perfluorodecanoate,perfluorooctanoate,perfluorononanoate,perfluoroundecanoate,perfluorododecanoate,perfluorotridecanoic acid,perfluoro tetradecanoict acid,perfluoro heptafluorobutyric acid,Perfluoropentanoic acid,Perfluoroheptanoic acid of residues in a variety of food with ion monitoring for positive confirmation. Sample was extracted with liquid-liquid extraction( LLE) and solid phase extraction( SPE) process. Eluted sample was determined by LC-MS /MS using external method. The detection limits,linear ranges,and recoveries were 1 μg / kg,1 ~ 100 μg / L and76. 50% ~ 110. 00%. This study established a method for determination of fluorocarbon surfactant in food. It is quickly,sensitive and can simultaneously determine many kinds of fluorocarbon surfactant and their positive confirmations.