Aquatic products are consumers' favorite products due to its nutrients and easy digestion.However,aquatic products are easy to deteriorate because of their higher water and protein content.The protein denaturation occurs frequently during frozen storage.Cryoprotectant is considered to be one of the most effective ways to prevent frozen aquatic products from protein denaturation.The cryoprotactants,such as saccharides,polyphosphates,hydrosol,proteins and hydrolysates have been widely studied.This study elaborated the denaturation mechanism of aquatic products.The relevant studies around the world and the application of proteins and polypeptides as cryoprotectants were discussed.The underlying mechanisms of cryoprotective effect were elucidated.This study provides a theoretical guidance for novel protein cryoprotectants.