Advances on synthesis of vitamin D by bio-chemical method

  • QU Lisha ,
  • YU Wenwen ,
  • LYU Xueqin ,
  • LI Jianghua ,
  • DU Guocheng ,
  • LIU Long
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  • 1(Science Center for Future Foods, Jiangnan University, Wuxi 214122, China)
    2(Key Laboratory of Carbohydrate Chemistry and Biotechnology, Jiangnan University, Wuxi 214122, China)

Received date: 2020-08-02

  Revised date: 2020-09-04

  Online published: 2021-02-03

Abstract

Vitamin D is a fat-soluble steroid hormone precursor, which plays an important role in balancing metabolism and maintaining body health. At present, the yield of traditional industrial production methods cannot satisfy the market demand. While, applying synthetic biology to synthesize sterol and using semi-chemical method to synthesize vitamin D is one of the effective ways to solve the contradiction. The research progress of the synthesis of vitamin D by bio-chemical method were reviewed, and dynamic regulation, metabolic compartmentalization and subcellular engineering were especially focused on. Besides, this review puts forward the possible challenges and solutions in the future production.

Cite this article

QU Lisha , YU Wenwen , LYU Xueqin , LI Jianghua , DU Guocheng , LIU Long . Advances on synthesis of vitamin D by bio-chemical method[J]. Food and Fermentation Industries, 2021 , 47(1) : 276 -284 . DOI: 10.13995/j.cnki.11-1802/ts.025246

References

[1] 罗金龙,姜淮芜.消化道重建术后维生素D研究进展[J].泸州医学院学报,2015(2):99-101.
LUO J L,JIANG H W.Research progress of vitamin D after digestive tract reconstruction[J].Journal of Luzhou Medical College,2015(2):99-101.
[2] SALEH J,TANG J,GAWINECKA W D,et al.Impact of a single oral dose of 100 000 IU vitamin D3 on profiles of serum 25(OH)D3 and its metabolites 24,25(OH)2D3,3-epi-25(OH)D3,and 1,25(OH)2D3 in adults with vitamin Dinsufficiency[J].Clinica Chimica Acta,2019:493.
[3] 姜艳, 夏维波.维生素D与佝偻病/骨软化症[J].中华骨质疏松和骨矿盐疾病杂志,2018,11(1):51-55.
JIANG Y,XIA W B.Vitamin D in rickets and osteomalacia[J].Chinese Journal of Osteoporosis and Bone Mineral Research,2018,11(1):51-55.
[4] AZARPEYKAN S,DITTMER K E,GEE E K,et al.Influence of blanketing and season on vitamin D and parathyroid hormone,calcium,phosphorus,and magnesium concentrations in horses in New Zealand[J].Domestic Animal Endocrinology,2016,56:75-84.
[5] RUILI D,YUJIN G,HUALIN C,et al.The effects of vitamin D on brain development and its implications for schizophrenia[J].Chinese Journal of Brain Diseases and Rehabilitation (Electronic Edition),2015,749:62-65.
[6] RENATE T D J,NATASJA M S,Paul L.Changes in vitamin D endocrinology during aging in adults[J].Molecular and Cellular Endocrinology,2017(453):44-150.
[7] GRANT,WILLIANM B.Vitamin D and incident dementia and cognitive impairment[J].American Journal of Clinical Nutrition,2017,106(2):699-700.
[8] CALVELLO R,NICOLARDI G,De N F,et al.Vitamin D treatment attenuates neuroinflammation and dopaminergic neurodegeneration in an animal model of Parkinson's disease,shifting M1 to M 2 microglia responses[J].Neuroimmune Pharmacology, 2016(12):327-339.
[9] EDITH A,PITTAS A G.The role of vitamin D in the prevention of type 2 diabetes:To D or not to D[J].Endocrinology,2017(7):7.
[10] MITRI J,DAWSON H B,HU F B,et al.Effects of vitamin D and calcium supplementation on pancreatic β cell function,insulin sensitivity,and glycemia in adults at high risk of diabetes:the calcium and vitamin D for diabetes mellitus (CaDDM) randomized controlled trial[J].Clinical Nutrition,2011,94(2):486.
[11] PEREIRA F,LARRIBA M J,MUNOZ A.Vitamin D and colon cancer[J].Cancer,2014(19):51-71.
[12] FELDMAN D,KRISHNAN A V,SWAMINA S,et al.The role of vitamin D in reducing cancer risk and progression[J].Nature Reviews Cancer,2014(14):342-357.
[13] MA Y,JOHNSON C S,et al.Mechanistic insights of vitamin D anticancer effects[J].Vitamins & Hormones,2016(100):395-431.
[14] KAMETANI T,FURUYAMA H.Synthesis of vitamin D3 and related compounds[J].Medicinal Research Reviews,1987,7(2):147-171.
[15] 张文倩, 周晓,肖文海,等.人工酵母后鲨烯路径基因对7-脱氢胆固醇合成的影响[J].中国生物工程杂志,2016,36(6):39-50.
ZHANG W Q,ZHOU X,XIAO W H,et al.Effect of post-squalene genes on the synthesis of 7-dehydrocholesterol in the artificial Saccharomyces cerevisiae[J].China Biotechnology,2016,36(6):39-50.
[16] SANG H Y,SOOK H L,et al.Combinatorial expression of bacterial whole mevalonate pathway for the production of β-carotene in E.coli[J].Biotechnology,2009(140):3-4.
[17] TAMANOI F,AZIZIAN M,ASHRAFI M,et al.Mevalonate pathway and human cancers[J].Current Molecular Pharmacology,2016,10(2):77-85.
[18] LIU J,ZHANG W,DU G,et al.Overproduction of geraniol by enhanced precursor supply in Saccharomyces cerevisiae[J].Biotechnology,2013(168):446-451.
[19] KEASLING J D.Synthetic biology and the development of tools for metabolic engineering[J].Metabolic Engineering,2012,14(3):189-195.
[20] GUO Z J,MING D Y,YING W,LIANG Z,TIAN Q S,et al.Manipulation of GES and ERG20 for.geraniol overproduction in Saccharomyces cerevisiae[J].Metabolic Engineering,2017(41):57-66.
[21] CUI S X,LV X Q,WU Y K,et al.Engineering a bifunctional Phr60-Rap60-Spo0A quorum-sensing molecular switch for dynamic fine-tuning of menaquinone-7 synthesis in Bacillus subtilis[J].ACS Synthetic Biology,2019,8(8):1826-1837.
[22] 林晓珊, 江宏文,张毅.酵母麦角固醇生物合成及其基因调控的研究[J].生物学杂志,2010,27(6):83-86.
LIN X S,JIANG H W,ZHANG Y.Studies on biosynthesis and gene regulation of ergosterol in yeast[J].Journal of Biology,2010,27(6):83-86.
[23] POLAKOWSKI T,BASTL R,STAHL U,LANG C.Enhanced sterol-acyl transferase activity promotes sterol accumulation in Saccharomyces cerevisiae[J].Applied Microbiology and Biotechnology,1999,53(1):30-35.
[24] HE X P,GUO X N,LIU N,ZHANG B.Ergosterol production from molasses by genetically modified Saccharomyces cerevisiae[J].Applied Microbiology and Biotechnology,2007,75(1):55-60.
[25] HU Z,HE B,MA L,et al.Recent advances in ergosterol biosynthesis and regulation mechanisms in Saccharomyces cerevisiae[J].Indian Journal of Microbiology,2017,57(3):270-277.
[26] 张莹,张璐,周晓.7-脱氢胆甾醇合成功能模块与底盘细胞的适配性[J].生物工程学报,2014,30(1):30-42.
ZHANG Y,ZHANG L,ZHOU X.Match of functional module with chassis in 7-dehydrocholesterol synthesis[J].Chinese Journal of Biotechnology,2014,30(1):30-42.
[27] 苏皖, 刘悦,周晓,等.生物合成7-脱氢胆甾醇酵母底盘的初探[J].化学工业与工程.2017,34(4):83-90.
SU W,LIU Y,ZHOU X,et al.The exploration of yeast chassis for 7-dehydrocholesterol biosynthesis[J].Chemical Industry and Engineering.2017,34(4):83-90.
[28] GUO X J,XIAO W H,WANG Y,YAO M D.Metabolic engineering of Saccharomyces cerevisiae for 7-dehydrocholesterol overproduction[J].Biotechnology for Biofuels,2018(11):146-156.
[29] NIELSEN J.Synthetic biology for engineering acetyl coenzyme A metabolism in yeast[J].Microbiology,2014(5):14-16.
[30] MEADOWS A L,HAWKINS K M,TSEGAYE Y,et al.Rewriting yeast central carbon metabolism for industrial isoprenoid production[J].Nature,2016(537):694-697.
[31] BIENERT S,WATERHOUSE A,TJAART A P,et al.The Swiss-model repository-new features and functionality[J].Nucleic Acids Research,2017(45):313-319.
[32] LV X,XIE W P,LU W Q,et al.Enhanced isoprene biosynthesis in Saccharomyces cerevisiae by engineering of the native acetyl-CoA and mevalonic acid pathways with a push-pullrestrain strategy[J].Biotechnology,2014(186):128-136.
[33] CERNIGLIA G J,DEY S.The PI3K/Akt pathway regulates oxygen metabolism via pyruvate dehydrogenase (PDH)-E1α phosphorylation[J].Molecular Cancer Therapeutics,2015,14(8):1 928-1 938.
[34] LIAN J,SI T,NAIR N U,et al.Design and construction of acetyl-CoA overproducing Saccharomyces cerevisiae strains[J].Metabolic Engineering,2014 (24):139-149.
[35] SU W,XIAO WH,WANG Y,et al.Alleviating redox imbalance enhances 7-dehydrocholesterol production in engineered Saccharomyces cerevisiae[J].PLoS One,2015(10):e0130840.
[36] GIONATA S,LAURENT D,JENS N,et al.Combined metabolic engineering of precursor and co-factor supply to increase α-santalene production by Saccharomyces cerevisiae[J].BioMed Central,2012,11(1):117-120.
[37] ANUM A,YAO M H,DANIEL J.Computational design of a modular protein sense-response system[J].Science,2019,366(6 468):1 024-1 028.
[38] CHRISTWARDANA M,FRATTINI D,DUARTE K D Z,et al.Carbon felt molecular modification and biofilm augmentation via quorum sensing approach in yeast-based microbial fuel cells[J].Applied Energy,2019,238(15):239-248.
[39] DRINNENBERG I A,WEINBERG D E,XIE K T,et al.RNAi in budding yeast[J].Science,2009(326):544-550.
[40] WILLIAMS T C,NIELSEN L K,VICKERS C E.Engineered quorum sensing using pheromone-mediated cell-to-cell communication in Saccharomyces cerevisiae[J].ACS Synthetic Biology,2013,2(3):136-149.
[41] WILLIAMS T C,WINTER G,PLAN M R,et al.Quorum-sensing linked RNA interference for dynamic metabolic pathway control in Saccharomyces cerevisiae[J].Metabolic Engineering,2015(29):124-134.
[42] HU J,DONG L,OUTTEN C E.The redox environment in the mitochondrial intermembrane space is maintained separately from the cytosol and matrix[J].Biological Chemistry,2008(283):29 126-29 134.
[43] DANIELLE Y A,BILLINGSLEY J M,CRESO J G.Engineered mitochondrial production of monoterpenes in Saccharomyces cerevisiae[J].Metabolic Engineering,2019(55):76-84.
[44] LIU G S,LI T,ZHOU W,et al.The yeast peroxisome:a dynamic storage depot and subcellular factory for squalene overproduction[J].Metabolic Engineering,2020(57):151-161.
[45] SCHUCK S,PRINZ W A,THORN K S,et al.Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response[J].Cell Biology,2009(187):525-536.
[46] KERFELD C A,AUSSIGNARGUES C,ZARZYCKI J,et al.Bacterial microcompartments[J].Nature Reviews Microbiology,2018,16:277-290.
[47] SWARTZ J.Transforming biochemical engineering with cell-free biology[J].AIChE Journal,2012(58):5-13.
[48] RODRIGUEZ S B,LEYH T S.An enzymatic platform for the synthesis of isoprenoid precursors[J].PLoS One,2014(9):e105594.
[49] ARNOLD F H.Directed evolution:bringing new chemistry to life[J].Angewandte Chemie International Edition,2018,57(16):4 143-4 148.
[50] SHELDON R A,PEREIRA P C.Biocatalysis engineering:the big picture[J].Chemical Society Reviews,2017,46(10):2 678-2 691.
[51] CHEN H,LI M,LIU C,ZHANG H,et al.Correction to:Enhancement of the catalytic activity of Isopentenyl diphosphate isomerase (IDI) from Saccharomyces cerevisiae through random and site-directed mutagenesis[J].Microbial Cell Factories,2020,19(1):8.
[52] CROOK N,ABATEMARCO J,SUN J,et al.In vivo continuous evolution of genes and pathways in yeast[J].Nature Communications,2016(7):1 035-1 035.
[53] FISHER M J,MEYER S,CLAUDEL P,et al.Metabolic engineering of monoterpene synthesis in yeast[J].Biotechnology Bioengineering,2011(108):1 883-1 892.
[54] HALPERIN S O,TOU C J,WONG E B,et al.CRISPR-guided DNA polymerases enable diversification of all nucleotides in a tunable window[J].Nature,2018,560:248-252.
[55] CHENG F,ZHU L L,SCHWANEBERG U.Directed evolution 2.0:improving and deciphering enzyme properties[J].Chemical Communications,2015,51(48):9 760-9 772.
[56] 苗景, 邓利,谭天伟.麦角固醇连续光转化生产维生素D2新工艺[J].北京化工大学学报,2003,30(3):39-41.
MIAO J,DENG L,TAN T W.A new method of continuous photolysis of ergosterol for production of vitamin D2[J].Journal of Beijing University of Chemical Technology,2003,30(3):39-41.
[57] 褚明辉, 郭建强,高殿昆.用新的紫外荧光光源对维生素D2的最佳光合成[J].发光学报,2000,21(1):65-67.
ZHU M H,GUO J Q,GAO D K.The optimum photochemical synthesis of vitamin-D2 by new ultraviolet fluorescence light source[J].Chinese Journal of Luminescence,2000,21(1):65-67.
[58] FUSE S.Continuous-flow synthesis of vitamin D3[J].Chemical Communications,2010,46(46):8 722-8 724.
[59] BENDIK I,FRIEDEL A,ROOS F F,et al.Vitamin D:A critical and essential micronutrient for human health[J].Frontiers in Physiology,2014,5:248.
[60] PILZ S,TRUMMER C,PANDIS M,et al.Vitamin D:Current guidelines and future outlook[J].Anticancer Research,2018(38):1 145-1 151.
[61] LIAN J,ZHAO H.Functional reconstitution of a pyruvate dehydrogenase in the cytosol of Saccharomyces cerevisiae through lipoylation machinery engineering[J].ACS Synthetic Biology,2016(5):689-697.
[62] DE G M R,ALEXEEVA S,SNOEP J L,et al.The steady-state internal redox state (NADH/NAD) reflects the external redox state and is correlated with catabolic adaptation in Escherichia coli[J].J Bacteriol,1999,181(8):2 351-2 357.
[63] STEPHANIE G,KATE T,TRENCHARD I J,et al.Complete biosynthesis of opioids in yeast[J].Science,2015(349):1 095-1 100.
[64] IGNEA C,PONTINI M,MAFFEI M E,et al.Engineering monoterpene production in yeast using a synthetic dominant negative geranyl diphosphate synthase[J].ACS Synthetic Biology,2014(3):298-306.
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