Evaluation of Auxis thazard oligopeptides on lowering uric acid

  • JI Wei ,
  • JI Hongwu
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  • 1(College of Biology and Food Engineering, Guangdong University of Education, Guangzhou 510303, China)
    2(College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China)

Received date: 2020-08-12

  Revised date: 2020-09-21

  Online published: 2021-04-15

Abstract

Hyperuricemia rat model was used to evaluate Auxis thazard oligopeptide (ATO) on lowering uric acid. The results showed that there was no significant difference in organ coefficients between 1.6 g/kg and 2.4 g/kg ATO groups compared with model group. Moreover, serum XOD showed a trend of decreasing first and then increasing, finally declining slowly, which indicated that XOD activity in the liver was significantly decreased in a short term. Besides, serum urea nitrogen and serum creatinine showed a downward trend, the blood uric acid content of 2.4 g/kg ATO group decreased significantly (P<0.05). The uric acid concentration and uric acid excretion in each test group were also significantly lower than those in the normal group (P<0.05). Futhermore, histopathological results showed that ATO had a certain protective effect on the kidney of hyperuricemia rats. However, the dose-effect relationship was not significant. Less urate deposition indicated a decrease in uric acid production to some extent. Therefore, ATO has a certain uric acid lowering effect even though with a little toxic side effects.

Cite this article

JI Wei , JI Hongwu . Evaluation of Auxis thazard oligopeptides on lowering uric acid[J]. Food and Fermentation Industries, 2021 , 47(6) : 62 -67 . DOI: 10.13995/j.cnki.11-1802/ts.025349

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