[1] SHI H T,LI S L,Bai Y Y,et al.A Mycotoxin contamination of food and feed in China occurrence,detection techniques,toxicological effects and advances in mitigation technologies[J].Food Control,2018,91:202-215.
[2] LOI M,FANELLI F,LIUZZI V C,et al.Mycotoxin biotransformation by native and commercial enzymes:Present and future perspectives[J].Toxins (Basel),2017,9(4):111-142.
[3] FRUHAUF S,NOVAK B,NAGL V,et al.Biotransformation of the mycotoxin zearalenone to its metabolites hydrolyzed zearalenone (hzen) and decarboxylated hydrolyzed zearalenone (dhzen) diminishes its estrogenicity in vitro and in vivo[J].Toxins,2019,11(8).DOI:10.3390/toxins11080481.
[4] SZABÓ-FODOR J,SZABÓ A,KÓCSÓ D,et al.Interaction between the three frequently co-occurring Fusarium mycotoxins in rats[J].Journal of Animal Physiology and Animal Nutrition,2019,103(1):370-382.
[5] ROGOWSKA A,POMASTOWSKI P,SAGANDYKOVA G,et al.Zearalenone and its metabolites:Effect on human health,metabolism and neutralisation methods[J].Toxicon,2019,162:46-56.
[6] GONZALEZ PEREYRA M L,DI GIACOMO AL,LARA A L,et al.Aflatoxin-degrading Bacillus sp.strains degrade zearalenone and produce proteases,amylases and cellulases of agro-industrial interest[J].Toxicon,2020,180:43-48.
[7] KALAGATUR N K,KAMASANI J R,MUDILI V.Assessment of detoxification efficacy of irradiation on zearalenone mycotoxin in various fruit juices by response surface methodology and elucidation of its in-vitro toxicity[J].Frontiers in Microbiology,2018,9:2 937-2 950.
[8] BAI X,SUN C,XU J,et al.Detoxification of zearalenone from corn oil by adsorption of functionalized GO systems[J].Applied Surface Science,2018,430:198-207.
[9] VILA-DONAT P,MARíN S,SANCHIS V,et al.A review of the mycotoxin adsorbing agents,with an emphasis on their multi-binding capacity,for animal feed decontamination[J].Food and Chemical Toxicology,2018,114:246-259.
[10] XU Y,WANG Y,JI J,et al.Chemical and toxicological alterations of zearalenone under ozone treatment[J].Food Additives & Contaminants:Part A,2019,36(1):163-174.
[11] TANG Y,XIAO J,CHEN Y,et al.Secretory expression and characterization of a novel peroxiredoxin for zearalenone detoxification in Saccharomyces cerevisiae[J].Microbiological Research,2013,168(1):6-11.
[12] YU Y,QIU L,WU H,et al.Oxidation of zearalenone by extracellular enzymes from Acinetobacter sp.SM04 into smaller estrogenic products[J].World Journal of Microbiology and Biotechnology,2011,27(11):2 675-2 681.
[13] YU Y,WU H,TANG Y,et al.Cloning,expression of a peroxiredoxin gene from Acinetobacter sp.SM04 and characterization of its recombinant protein for zearalenone detoxification[J].Microbiological Research,2012,167(3):121-126.
[14] LOI M,FANELLI F,CIMMARUSTI M T,et al.In vitro single and combined mycotoxins degradation by Ery4 laccase from Pleurotus eryngii and redox mediators[J].Food Control,2018,90:401-406.
[15] 卢丹, 徐晴,江凌,等.生物酶降解真菌毒素的研究进展[J].生物加工过程,2018,16(2):49-56.
LU D,XU Q,JIANG L,et al.Advances in enzymatic detoxification of mycotoxins[J].The Chinese Journal of Bioprocessing Engineering,2018,16(2):49-56
[16] TAKAHASHI-ANDO N,KIMURA M,KAKEYA H,et al.A novel lactonohydrolase responsible for the detoxification of zearalenone:Enzyme purification and gene cloning[J].Biochemical Journal,2002,365:1-6.
[17] YU X,TU T,LUO H,et al.Biochemical characterization and mutational analysis of a lactone hydrolase from Phialophora americana[J].Journal of Agricultural and Food Chemistry,2020,68(8):2 570-2 577.
[18] TAKAHASHI-ANDO N,OHSATO S,SHIBATA T,et al.Metabolism of zearalenone by genetically modified organisms expressing the detoxification gene from Clonostachys rosea[J].Applied Environmental and Microbiology,2004,70(6):3 239-3 345.
[19] YANG W C,HSU T C,CHENG K C,et al.Expression of the Clonostachys rosea lactonohydrolase gene by Lactobacillus reuteri to increase its zearalenone-removing ability[J].Microbial Cell Factories,2017,16(1):1-11.
[20] BI K,ZHANG W,XIAO Z,et al.Characterization,expression and application of a zearalenone degrading enzyme from Neurospora crassa[J].AMB Express,2018,8(1):1-10.
[21] WANG M,YIN L,HU H,et al.Expression,functional analysis and mutation of a novel neutral zearalenone-degrading enzyme[J].International Journal of Biological Macromolecules,2018,118:1 284-1 292.
[22] HUI R,HU X,LIU W,et al.Characterization and crystal structure of a novel zearalenone hydrolase from Cladophialophora bantiana[J].Acta Cryst F Structural Biological Communications,2017,73(Pt 9):515-519.
[23] XIANG L,WANG Q,ZHOU Y,et al.High-level expression of a ZEN-detoxifying gene by codon optimization and biobrick in Pichia pastoris[J].Microbiological Research,2016,193:48-56.
[24] 胡翔颖, 刘文婷,刘卫东,等.来源于Rhinocladiella mackenziei的玉米赤霉烯酮水解酶的表达纯化与酶学性质[J].微生物学通报,2018,45(12):2 585-2 591.
HU X Y,LIU W T,LIU W D,et al.Expression,purification and characterization of a novel zearalenone hydrolase from Rhinocladiella mackenziei[J].Microbiology China,2018,45(12):2 585-2 591.
[25] 刘海燕, 孙长坡,伍松陵,等.玉米赤霉烯酮毒素降解酶基因的克隆及在毕赤酵母中的高效表达[J].中国粮油学报,2011,26:12-17.
LIU H Y,SUN C P,WU S L,et al.Expression of zearalenone degrading enzyme gene from Gliocladium roseum in Pichia pastoris GS115[J].Journal of the Chinese Cereals and Oils Association,2011,26:12-17.
[26] 程波财, 史文婷,罗洁,等.玉米赤霉烯酮降解酶基因(ZEN-jjm)的克隆、表达及活性分析[J].农业生物技术学报,2010,18(2):225-230.
CHENG B C,SHI W T,LUO H,et al.Cloning of zearalenone-degraded enzyme gene (ZEN-jjm) and its expression and activity analysis[J].Journal Of Agricultural Biotechnology,2010,18(2):225-230.
[27] ZHANG Z X,XU W,WU H,et al.Identification of a potent enzyme for the detoxification of zearalenone[J].Journal of Agricultural and Food Chemistry,2020,68(1):376-383.
[28] LIU Q,XUN G,FENG Y.The state-of-the-art strategies of protein engineering for enzyme stabilization[J].Biotechnology Advances,2019,37(4):530-537.
[29] XU Z,LIU W,CHEN C C,et al.Enhanced α-zearalenol hydrolyzing activity of a mycoestrogen-detoxifying lactonase by structure-based engineering[J].ACS Catalysis,2016,6(11):7 657-7 663.
[30] ZHENG Y,LIU W,CHEN C C,et al.Crystal structure of a mycoestrogen-detoxifying lactonase from Rhinocladiella mackenziei:Molecular insight into ZHD substrate selectivity[J].ACS Catalysis,2018,8(5):4 294-4 298.
[31] PENG W,KO T P,YANG Y,et al.Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea[J].RSC Advances,2014,4(107):62 321-62 325.
[32] 许中霞, 刘桂智,刘卫东,等.玉米赤霉烯酮水解酶耐热性的分子改造[J].食品与生物技术学报,2019,38(7):71-77.
XU Z X,LIU G Z,LIU W D,et al.Molecular engineering of mycoestrogen-detoxifying lactonase ZHD101 to improve enzyme thermostability[J].Journal of Food Science and Biotechnology,2019,38(7):71-77.
[33] 王壬丰, 周峻岗,胡小健,等.玉米赤霉烯酮降解酶在马克斯克鲁维酵母中的 表达及高产菌株的诱变筛选[J].复旦学报(自然科学版),2017,56(4):431-437.
WANG R F,ZHOU J G,HU X J,et al.Expression of ZHD1O1 in Kluyveromyces marxianus and the mutation breeding of high-field strain[J].Journal of Fudan University(Natural Science),2017,56(4):431-437.
[34] HE M,LI Y,PI F,et al.A novel detoxifying agent:Using rice husk carriers to immobilize zearalenone-degrading enzyme from Aspergillus niger FS10[J].Food Control,2016,68:271-279.
[35] 王浩宇, 孙晶,常晓娇,等.玉米赤霉烯酮降解酶ZLHY6的包埋及稳定性研究[J].粮油食品科技,2018,26(2):63-67.
WANG H Y,SUN J,CHANG X J,et al.Study on the embedding and stability of zearalenone degrading enzyme ZLHY6[J].Science and Technology of Cereals,Oils and Foods,2018,26(2):63-67.
[36] FILEK M,SIEPRAWSKA A,KOS′CIELNIAK J,et al.The role of chloroplasts in the oxidative stress that is induced by zearalenone in wheat plants-The functions of 24-epibrassinolide and selenium in the protective mechanisms[J].Plant Physiology and Biochemistry,2019,137:84-92.
[37] FAISAL Z,FLISZÁR-NYÙL E,DELLAFIORA L,et al.Interaction of zearalenone-14-sulfate with cyclodextrins and the removal of the modified mycotoxin from aqueous solution by beta-cyclodextrin bead polymer[J].Journal of Molecular Liquids,2020,310.DOI:10.1016/j.molliq.2020.113236.
[38] HIGA-NISHIYAMA A,TAKAHASHI-ANDO N,SHIMIZU T,et al.A model transgenic cereal plant with detoxification activity for the estrogenic mycotoxin zearalenone[J].Transgenic Research,2005,14(5):713-717.
[39] IGAWA T,TAKAHASHI-Ando N,OCHIAi N,et al.Reduced contamination by the Fusarium mycotoxin zearalenone in maize kernels through genetic modification with a detoxification gene[J].Applied and Environmenal Microbiology,2007,73(5):1 622-1 629.
