The model group of acute colitis was induced by dextran sulfate sodium (DSS). The effect of penicillin and Lactobacillus plantarum AR113 on model group were studied by detect the symptoms of colitis, inflammation level and intestinal barrier. The results showed that the disease activity index (DAI), body weight, myeloperoxidase (MPO) activity, tissue damage and inflammatory in penicillin group were lower than the model group, which suggesting that the sensitivity of DSS-induced colitis was inactivated by penicillin. The combined treatment of penicillin and AR113 group exhibited lower colitis symptom than that of the model group, but no significant different to the penicillin group. In addition, the recovery of intestinal mucus layer showed no significant difference between the penicillin group and the combined treatment group. However, the recovery ability on intestinal mucus layer in AR113 group was better than the penicillin group and combined treatment group. In conclusion the treatment of AR113 gavage affect little on the recovery of intestinal mucus layer after penicillin intervention, while penicillin will reduce the recovery effect of the mucus layer.
TIAN Miaoxin
,
SHAO Junlin
,
WANG Guangqiang
,
XIONG Zhiqiang
,
ZHANG Hui
,
SONG Xin
,
AI Lianzhong
,
XIA Yongjun
. Comparative effect of Lactobacillus plantarum AR113 and penicillin on DSS-induced colitis in mice[J]. Food and Fermentation Industries, 2021
, 47(17)
: 105
-110
.
DOI: 10.13995/j.cnki.11-1802/ts.026483
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